HLA-B58:01 and rs9263726 have a linkage, but not absolute linkage disequilibrium in Han Chinese population
HLA-B*58:01 has been demonstrated to be associated with allopurinol-induced severe cutaneous adverse reactions. Since HLA-B*58:01 is too complicated to be identified, it is necessary to select an appropriate surrogate biomarker. In Japan, the rs9263726 allele was considered as a surrogate biomarker...
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| Veröffentlicht in: | Drug metabolism and pharmacokinetics 2018-10, Vol.33 (5), p.228-231 |
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| creator | Dou, Yaling Peng, Pan Cai, Congli Ye, Ali Kong, Lingjun Zhang, Rui |
| description | HLA-B*58:01 has been demonstrated to be associated with allopurinol-induced severe cutaneous adverse reactions. Since HLA-B*58:01 is too complicated to be identified, it is necessary to select an appropriate surrogate biomarker. In Japan, the rs9263726 allele was considered as a surrogate biomarker for HLA-B*58:01, but this was not the case with the Australian cohort. Due to the conflict results, in this study, we aim to demonstrate whether the rs9263726 allele is a surrogate biomarker for HLA-B*58:01 in Han Chinese population. A total of 353 samples (200 cases from the south and 153 cases from the north) were selected to detect HLA-B*58:01 and rs9263726 allele. The HLA-B*58:01 was identified by sequencing-based method, and the rs9263726 allele was identified by Taqman SNP Genotyping Assays. The results showed that the two alleles had a linkage, but not absolute linkage disequilibrium in Han Chinese population.
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| doi_str_mv | 10.1016/j.dmpk.2018.08.001 |
| format | Article |
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[Display omitted]</description><subject>Alleles</subject><subject>Allopurinol-induced SCARs</subject><subject>China</subject><subject>Ethnic Groups - genetics</subject><subject>Genotype</subject><subject>Han Chinese</subject><subject>HLA-B Antigens - genetics</subject><subject>HLA-B58:01</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>rs9263726</subject><issn>1347-4367</issn><issn>1880-0920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFr3DAQhUVJ6W6T_IEcio451JuRZFtW6WWztN3CQi_JWUj2ONGuLXslO5B_Xy2b9FgYmIF578H7CLlhsGLAyrv9qunHw4oDq1aQBtgHsmRVBRkoDhfpFrnMclHKBfkc4x5AiCLnn8hCAFOiYnxJ9tvdOrsvqm_AqPENDVHxUkhe0mfzgtTQzvmDecKv1M4T9cNEjY1DN0_4_qGNi3icXedscHNPnadb4-nm2XmMSMdhnDszucFfkY-t6SJev-1L8vjzx8Nmm-3-_Pq9We-yOi9gylploM5bLpuiAKtEi0xKxjlIsI0qGJbKgpCibUuZgzUq1betLaRSPEeL4pLcnnPHMBxnjJPuXayx64zHYY6aJ3i8lAJUkvKztA5DjAFbPQbXm_CqGegTY73XJ8b6xFhDGmDJ9OUtf7Y9Nv8s71CT4PtZgKnli8OgY-3Q19i4gPWkm8H9L_8vb_eKtw</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Dou, Yaling</creator><creator>Peng, Pan</creator><creator>Cai, Congli</creator><creator>Ye, Ali</creator><creator>Kong, Lingjun</creator><creator>Zhang, Rui</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20181001</creationdate><title>HLA-B58:01 and rs9263726 have a linkage, but not absolute linkage disequilibrium in Han Chinese population</title><author>Dou, Yaling ; Peng, Pan ; Cai, Congli ; Ye, Ali ; Kong, Lingjun ; Zhang, Rui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-f9a0c4f27d550b93fe177122070bd951e69b0373ff6740ba9018bfb579924ebe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alleles</topic><topic>Allopurinol-induced SCARs</topic><topic>China</topic><topic>Ethnic Groups - genetics</topic><topic>Genotype</topic><topic>Han Chinese</topic><topic>HLA-B Antigens - genetics</topic><topic>HLA-B58:01</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>rs9263726</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dou, Yaling</creatorcontrib><creatorcontrib>Peng, Pan</creatorcontrib><creatorcontrib>Cai, Congli</creatorcontrib><creatorcontrib>Ye, Ali</creatorcontrib><creatorcontrib>Kong, Lingjun</creatorcontrib><creatorcontrib>Zhang, Rui</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug metabolism and pharmacokinetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dou, Yaling</au><au>Peng, Pan</au><au>Cai, Congli</au><au>Ye, Ali</au><au>Kong, Lingjun</au><au>Zhang, Rui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-B58:01 and rs9263726 have a linkage, but not absolute linkage disequilibrium in Han Chinese population</atitle><jtitle>Drug metabolism and pharmacokinetics</jtitle><addtitle>Drug Metab Pharmacokinet</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>33</volume><issue>5</issue><spage>228</spage><epage>231</epage><pages>228-231</pages><issn>1347-4367</issn><eissn>1880-0920</eissn><abstract>HLA-B*58:01 has been demonstrated to be associated with allopurinol-induced severe cutaneous adverse reactions. Since HLA-B*58:01 is too complicated to be identified, it is necessary to select an appropriate surrogate biomarker. In Japan, the rs9263726 allele was considered as a surrogate biomarker for HLA-B*58:01, but this was not the case with the Australian cohort. Due to the conflict results, in this study, we aim to demonstrate whether the rs9263726 allele is a surrogate biomarker for HLA-B*58:01 in Han Chinese population. A total of 353 samples (200 cases from the south and 153 cases from the north) were selected to detect HLA-B*58:01 and rs9263726 allele. The HLA-B*58:01 was identified by sequencing-based method, and the rs9263726 allele was identified by Taqman SNP Genotyping Assays. The results showed that the two alleles had a linkage, but not absolute linkage disequilibrium in Han Chinese population.
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| subjects | Alleles Allopurinol-induced SCARs China Ethnic Groups - genetics Genotype Han Chinese HLA-B Antigens - genetics HLA-B58:01 Humans Linkage Disequilibrium rs9263726 |
| title | HLA-B58:01 and rs9263726 have a linkage, but not absolute linkage disequilibrium in Han Chinese population |
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