Evaluation of anti-sleeping-sickness drugs and topoisomerase inhibitors in combination on Trypanosoma brucei
The trypanocidal activities of combinations of anti-human African trypanosomiasis drugs (eornithine, melarsoprol, pentamidine and suramin), DNA topoisomerase I inhibitors [topotecan and 7-ethyl-10-hydroxycamptothecin (SN-38; the active compound of irinotecan)] and DNA topoisomerase II inhibitors (ac...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2009-06, Vol.63 (6), p.1293-1295 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Steverding, Dietmar Wang, Xia |
| description | The trypanocidal activities of combinations of anti-human African trypanosomiasis drugs (eornithine, melarsoprol, pentamidine and suramin), DNA topoisomerase I inhibitors [topotecan and 7-ethyl-10-hydroxycamptothecin (SN-38; the active compound of irinotecan)] and DNA topoisomerase II inhibitors (aclarubicin, daunorubicin, doxorubicin, epirubicin, idarubicin and mitoxantrone) against bloodstream forms of Trypanosoma brucei cultured in vitro were investigated. Results suggest that the combination of eornithine and mitoxantrone could be a potential alternative treatment for HAT. |
| doi_str_mv | 10.1093/jac/dkp120 |
| format | Article |
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Results suggest that the combination of eornithine and mitoxantrone could be a potential alternative treatment for HAT.</description><subject>Animals</subject><subject>Antimicrobial agents</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Chemotherapy</subject><subject>DNA topoisomerase inhibitors</subject><subject>drug combinations</subject><subject>Drug Synergism</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Humans</subject><subject>Inhibitor drugs</subject><subject>Inhibitory Concentration 50</subject><subject>Parasitic diseases</subject><subject>Parasitic Sensitivity Tests</subject><subject>Pharmacology</subject><subject>T. brucei</subject><subject>Trypanosoma brucei</subject><subject>Trypanosoma brucei brucei - drug effects</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1rFTEUBuAgir2tbvwBMgi6EMaefN9ZammtUnBhleImZDKZmntnkjFnRtp_b2QuCi5c5UAeXg7nJeQZhTcUGn66s-6020-UwQOyoUJBzaChD8kGOMhaC8mPyDHiDgCUVNvH5Ig2nCsh5YYM5z_tsNg5pFilvrJxDjUO3k8h3tYY3D56xKrLyy2Wz66a05QCptFni74K8Xtow5wylrFyaWxDPGTF6jrfTzamgm3V5sX58IQ86u2A_unhPSFfLs6vzy7rq0_vP5y9vaqdEHque6BlOcW3DbRaANeSUQ0MeumdpL6RW6aazlLhgUmqXNuC66V1oufCdUzxE_JqzZ1y-rF4nM0Y0PlhsNGnBQ2jQBlXtMAX_8BdWnIsuxWj1ZaD1gW9XpHLCTH73kw5jDbfGwrmdwGmFGDWAgp-fkhc2tF3f-nh4gW8XEFapv8H1asLOPu7P9LmvVG6nMRc3nwzny_Y13cfb6QR_Bee6Z4f</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Steverding, Dietmar</creator><creator>Wang, Xia</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>20090601</creationdate><title>Evaluation of anti-sleeping-sickness drugs and topoisomerase inhibitors in combination on Trypanosoma brucei</title><author>Steverding, Dietmar ; 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the active compound of irinotecan)] and DNA topoisomerase II inhibitors (aclarubicin, daunorubicin, doxorubicin, epirubicin, idarubicin and mitoxantrone) against bloodstream forms of Trypanosoma brucei cultured in vitro were investigated. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Antimicrobial agents Antiprotozoal Agents - pharmacology Chemotherapy DNA topoisomerase inhibitors drug combinations Drug Synergism Enzyme Inhibitors - pharmacology Humans Inhibitor drugs Inhibitory Concentration 50 Parasitic diseases Parasitic Sensitivity Tests Pharmacology T. brucei Trypanosoma brucei Trypanosoma brucei brucei - drug effects |
| title | Evaluation of anti-sleeping-sickness drugs and topoisomerase inhibitors in combination on Trypanosoma brucei |
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