An assessment of mutagenic effect of 3,3',4,4',5 pentachlorobiphenyl (PCB126) in Muta Mouse fetuses

PCBs are persistent environmental agents that induce multiple impairments in living beings. In this study we used a transgenic mouse model (Mutasup(TM) Mouse), carrying bacterial lacZ genes for mutation assays and for assessment of the genotoxic effect of PCB126 on fetal mice. Mothers of experimenta...

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Veröffentlicht in:	Journal of Veterinary Medical Science 2009, Vol.71(4), pp.529-533
Hauptverfasser:	Inomata, T.(Azabu Univ., Sagamihara, Kanagawa (Japan). Azabu Univ., Sagamihara, Kanagawa (Japan). School of Veterinary Medicine), Sekiguchi, M, Hirayama, S, Akahori, F, Shirai, M, Kashiwazaki, N, Ito, J, Hisamatsu, S, Sakita, K, Ninomiya, H
Format:	Artikel
Sprache:	eng
Schlagworte:	ANIMAL TRANSGENIQUE ANIMALES TRANSGENICOS Animals beta-Galactosidase - genetics BIFENILOS POLICLORADOS Body Weight - drug effects Cleft Palate - chemically induced DNA - genetics Female FETO fetus Fetus - drug effects FOETUS Maternal Exposure MICE Mice, Inbred BALB C Mice, Inbred DBA Mice, Transgenic muta mouse MUTAGENICIDAD MUTAGENICITE MUTAGENICITY Mutagenicity Tests - methods Mutagenicity Tests - veterinary Organ Size - drug effects PCB126 POLYCHLORINATED BIPHENYLS Polychlorinated Biphenyls - toxicity POLYCHLORURE DE BIPHENYLE Pregnancy RATON SOURIS TRANSGENIC ANIMALS
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