Lentiviral Vector-Mediated SHC3 Silencing Exacerbates Oxidative Stress Injury in Nigral Dopamine Neurons by Regulating the PI3K-AKT-FoxO Signaling Pathway in Rats with Parkinson’s Disease

Parkinson's disease (PD) is a prevalent disease that leads to motor and cognitive disabilities, and oxidative stress (OS) injury was found to be related to the etiology of PD. Increasing evidence has shown that SHC3 is aberrantly expressed in neurons. The current study examines the involvement...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018-01, Vol.49 (3), p.971-984
Hauptverfasser:	Gong, Jian, Zhang, Lei, Zhang, Qian, Li, Xiang, Xia, Xiang-Jun, Liu, Yin-Yuan, Yang, Qin-Shang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Behavior, Animal Brain Cell cycle Disease Models, Animal Dopamine Dopaminergic Neurons - metabolism Forkhead Transcription Factors - metabolism Gene silencing Kinases Laboratory animals Lentivirus - genetics Male Malondialdehyde - metabolism Metabolism Neurons Oxidative Stress Oxidative stress injury Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease PC12 Cells Phosphatidylinositol 3-Kinases - metabolism Physiology PI3K-AKT-FoxO signaling pathway Prostate cancer Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Retracted Paper RNA Interference RNA, Small Interfering - metabolism Rodents SHC3 Signal Transduction Src Homology 2 Domain-Containing, Transforming Protein 3 - antagonists & inhibitors Src Homology 2 Domain-Containing, Transforming Protein 3 - genetics Src Homology 2 Domain-Containing, Transforming Protein 3 - metabolism Stress response Superoxide Dismutase - metabolism Transcription factors
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