Body composition and insulin resistance in children
Insulin resistance is a condition of gluco-metabolic sufferance that may hesitate in the further development of type 2 diabetes and cardiovascular disease. The development of insulin resistance is mostly associated with the accumulation of excessive fat in the body. The epidemic impact of obesity in...
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| Veröffentlicht in: | European journal of clinical nutrition 2018-09, Vol.72 (9), p.1239-1245 |
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| description | Insulin resistance is a condition of gluco-metabolic sufferance that may hesitate in the further development of type 2 diabetes and cardiovascular disease. The development of insulin resistance is mostly associated with the accumulation of excessive fat in the body. The epidemic impact of obesity in the youngest promoted an increase of the prevalence of insulin resistance also in children and adolescents. Increased fat accumulation in the peri-visceral area of the abdomen, occurring preferably at and after puberty, and in the liver, as non-alcoholic fatty liver disease, plays a role in the process. After puberty, males are at higher risk than females to develop insulin resistance. Also ethnicity contributes to sensitivity of children to develop insulin resistance, where Hispanics, South-Asians, and Indians are at higher risk than Whites and Blacks.
In spite of the research progress in the field, several questions on the relationship between body composition and insulin resistance are still unanswered. Multiomics approach, combined with nutrition as well as imaging techniques might contribute to unravel the role of body composition on insulin resistance. |
| doi_str_mv | 10.1038/s41430-018-0239-2 |
| format | Article |
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In spite of the research progress in the field, several questions on the relationship between body composition and insulin resistance are still unanswered. Multiomics approach, combined with nutrition as well as imaging techniques might contribute to unravel the role of body composition on insulin resistance.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-018-0239-2</identifier><identifier>PMID: 30185840</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163/2743/393 ; 692/499 ; Accumulation ; Adolescents ; Asians ; Body composition ; Cardiovascular diseases ; Childhood obesity ; Children ; Clinical Nutrition ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Epidemics ; Epidemiology ; Fatty liver ; Glucose ; Imaging techniques ; Insulin ; Insulin resistance ; Internal Medicine ; Liver ; Liver diseases ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Minority & ethnic groups ; Nutrition ; Obesity ; Perspective ; Physiological research ; Puberty ; Public Health ; Type 2 diabetes</subject><ispartof>European journal of clinical nutrition, 2018-09, Vol.72 (9), p.1239-1245</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c574t-bb9bb84f90a01b7ccba1eaef661a04e51fbf388589d31b192ea558b18c125c1c3</citedby><cites>FETCH-LOGICAL-c574t-bb9bb84f90a01b7ccba1eaef661a04e51fbf388589d31b192ea558b18c125c1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41430-018-0239-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41430-018-0239-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30185840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maffeis, Claudio</creatorcontrib><creatorcontrib>Morandi, Anita</creatorcontrib><title>Body composition and insulin resistance in children</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Insulin resistance is a condition of gluco-metabolic sufferance that may hesitate in the further development of type 2 diabetes and cardiovascular disease. The development of insulin resistance is mostly associated with the accumulation of excessive fat in the body. The epidemic impact of obesity in the youngest promoted an increase of the prevalence of insulin resistance also in children and adolescents. Increased fat accumulation in the peri-visceral area of the abdomen, occurring preferably at and after puberty, and in the liver, as non-alcoholic fatty liver disease, plays a role in the process. After puberty, males are at higher risk than females to develop insulin resistance. Also ethnicity contributes to sensitivity of children to develop insulin resistance, where Hispanics, South-Asians, and Indians are at higher risk than Whites and Blacks.
In spite of the research progress in the field, several questions on the relationship between body composition and insulin resistance are still unanswered. Multiomics approach, combined with nutrition as well as imaging techniques might contribute to unravel the role of body composition on insulin resistance.</description><subject>692/163/2743/393</subject><subject>692/499</subject><subject>Accumulation</subject><subject>Adolescents</subject><subject>Asians</subject><subject>Body composition</subject><subject>Cardiovascular diseases</subject><subject>Childhood obesity</subject><subject>Children</subject><subject>Clinical Nutrition</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Fatty liver</subject><subject>Glucose</subject><subject>Imaging techniques</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Internal Medicine</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Minority & ethnic groups</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Perspective</subject><subject>Physiological research</subject><subject>Puberty</subject><subject>Public Health</subject><subject>Type 2 diabetes</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kk2LFDEQhoMo7rj6A7zIgCBeeq18dSfHdfELFrzoOSTp6pks3cmYdB_232-aWV1XRnIIVD1vUbz1EvKawgUFrj4UQQWHBqhqgHHdsCdkQ0XXNrIV8JRsQEvRcIDujLwo5QagNjv2nJzxKpFKwIbwj6m_3fo0HVIJc0hxa2O_DbEsY4jbjCWU2UaPtbT1-zD2GeNL8mywY8FX9_85-fn504-rr8319y_fri6vGy87MTfOaeeUGDRYoK7z3lmKFoe2pRYESjq4gau6h-45dVQztFIqR5WnTHrq-Tl5f5x7yOnXgmU2Uygex9FGTEsxjAJwDi0TFX37D3qTlhzrdoaB1koxLtkDtbMjmhCHNGfr16HmUnZMKa3ZSjUnqB1GzHZMEYdQy4_4ixN8fT1OwZ8UvPtLsEc7zvuSxmW1vzwG6RH0OZWScTCHHCabbw0FsybAHBNg6jnNmgCzat7cO7G4Cfs_it8nrwA7AqW24g7zg1X_n3oHjl-3Vw</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Maffeis, Claudio</creator><creator>Morandi, Anita</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180901</creationdate><title>Body composition and insulin resistance in children</title><author>Maffeis, Claudio ; 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The development of insulin resistance is mostly associated with the accumulation of excessive fat in the body. The epidemic impact of obesity in the youngest promoted an increase of the prevalence of insulin resistance also in children and adolescents. Increased fat accumulation in the peri-visceral area of the abdomen, occurring preferably at and after puberty, and in the liver, as non-alcoholic fatty liver disease, plays a role in the process. After puberty, males are at higher risk than females to develop insulin resistance. Also ethnicity contributes to sensitivity of children to develop insulin resistance, where Hispanics, South-Asians, and Indians are at higher risk than Whites and Blacks.
In spite of the research progress in the field, several questions on the relationship between body composition and insulin resistance are still unanswered. Multiomics approach, combined with nutrition as well as imaging techniques might contribute to unravel the role of body composition on insulin resistance.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30185840</pmid><doi>10.1038/s41430-018-0239-2</doi><tpages>7</tpages></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | 692/163/2743/393 692/499 Accumulation Adolescents Asians Body composition Cardiovascular diseases Childhood obesity Children Clinical Nutrition Diabetes mellitus Diabetes mellitus (non-insulin dependent) Epidemics Epidemiology Fatty liver Glucose Imaging techniques Insulin Insulin resistance Internal Medicine Liver Liver diseases Medicine Medicine & Public Health Metabolic Diseases Minority & ethnic groups Nutrition Obesity Perspective Physiological research Puberty Public Health Type 2 diabetes |
| title | Body composition and insulin resistance in children |
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