C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37

Cell migration is central to evoking a potent immune response. Dendritic cell (DC) migration to lymph nodes is dependent on the interaction of C-type lectin-like receptor 2 (CLEC-2; encoded by the gene ), expressed by DCs, with podoplanin, expressed by lymph node stromal cells, although the underlyi...

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Veröffentlicht in:	Journal of cell science 2018-10, Vol.131 (19)
Hauptverfasser:	de Winde, Charlotte M, Matthews, Alexandra L, van Deventer, Sjoerd, van der Schaaf, Alie, Tomlinson, Neil D, Jansen, Erik, Eble, Johannes A, Nieswandt, Bernhard, McGettrick, Helen M, Figdor, Carl G, Tomlinson, Michael G, Acton, Sophie E, van Spriel, Annemiek B
Format:	Artikel
Sprache:	eng
Schlagworte:	Actomyosin - metabolism Animals Antigens, CD - metabolism Antigens, Neoplasm - metabolism Cell Adhesion Cell Movement Cell Surface Extensions - metabolism Dendritic Cells - cytology Dendritic Cells - metabolism Endothelial Cells - metabolism HEK293 Cells Humans Interleukin-6 - biosynthesis Lectins, C-Type - metabolism Male Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Myeloid Cells - metabolism Protein Binding RAW 264.7 Cells Tetraspanins - deficiency Tetraspanins - metabolism
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