JMJD6 regulates histone H2A.X phosphorylation and promotes autophagy in triple-negative breast cancer cells via a novel tyrosine kinase activity

Overexpression of Jumonji domain-containing 6 (JMJD6) has been reported to be associated with more aggressive breast cancer characteristics. However, the precise role of JMJD6 in breast cancer development remains unclear. Here, we demonstrate that JMJD6 has intrinsic tyrosine kinase activity and can...

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Veröffentlicht in:	Oncogene 2019-02, Vol.38 (7), p.980-997
Hauptverfasser:	Liu, Yan, Long, Yue-Hong, Wang, Shu-Qing, Zhang, Yuan-Yue, Li, Yu-Feng, Mi, Jiang-Sheng, Yu, Cheng-Hua, Li, De-Yan, Zhang, Jing-Hua, Zhang, Xiao-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/44 13/51 14/19 14/28 38/39 38/61 38/77 631/337/458/1733 631/337/572 631/67/1347 631/67/395 631/80/39 64/60 82/80 Amino acids Animals Apoptosis Autophagy Breast cancer Cancer cells Care and treatment Cell Biology Development and progression Female Gene expression Genetic aspects Guanosine triphosphate Health aspects Histone H2A Histones - genetics Histones - metabolism Human Genetics Humans Internal Medicine Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Kinases Medicine Medicine & Public Health Mice Mice, Inbred BALB C Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oncology Oxidoreductases Phagocytosis Phenols (Class of compounds) Phosphates Phosphorylation Protein-tyrosine kinase Triple negative breast cancer Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tyrosine
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