Synthesis of Chiral Homoallylic Nitriles by Iridium-Catalyzed Allylation of Cyanoacetates

A synthesis of chiral homoallylic nitriles by the iridium-catalyzed allylation of cyanoacetates followed by Krapcho demethoxycarbonylation has been developed. A wide range of homoallylic nitriles were obtained with a high enantioselectivity (>95–99% ee). These compounds are useful chiral building...

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Veröffentlicht in:	Journal of organic chemistry 2018-10, Vol.83 (19), p.12239-12246
Hauptverfasser:	Matsunami, Asuka, Takizawa, Kazuki, Sugano, Shogo, Yano, Yusuke, Sato, Hiroaki, Takeuchi, Ryo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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