Evaluation of samidorphan, a μ‐opioid antagonist, in a drug discrimination assay in rats

Preclinical Research & Development Background: Samidorphan, a μ‐opioid receptor antagonist, is in clinical development for central nervous system related diseases. The discriminative stimulus effects of samidorphan were assessed in rats trained to discriminate the effects of a known morphinan of...

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Veröffentlicht in:	Drug development research 2018-08, Vol.79 (5), p.234-238
Hauptverfasser:	Sgro, Mario P., Modlin, Deah L., Deaver, Daniel R., Kallman, Mary J., Todtenkopf, Mark S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abuse Analgesia Animals antagonist Central nervous system Discrimination (Psychology) Dose-Response Relationship, Drug Drug discrimination Humans Male Morphine Morphine - pharmacology Naltrexone - analogs & derivatives Naltrexone - pharmacokinetics Naltrexone - pharmacology Narcotic Antagonists - pharmacokinetics Narcotic Antagonists - pharmacology Narcotics opioid Opioid receptors Pain perception Pharmacodynamics Pharmacology Rats Rats, Sprague-Dawley Receptors, Opioid, mu - antagonists & inhibitors Reinforcement Rodents
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