Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease

Parkinson’s disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which are primarily composed of α-synuclein. Post-translational modifications of α-synuclein induced b...

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Veröffentlicht in:	ACS chemical neuroscience 2019-02, Vol.10 (2), p.777-782
Hauptverfasser:	He, Yixi, Yu, Zhongwang, Chen, Shengdi
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Animals Brain - metabolism Brain - pathology Humans Nitrosative Stress - physiology Parkinson Disease - metabolism Parkinson Disease - pathology Protein Aggregates - physiology
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