Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease
Parkinson’s disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which are primarily composed of α-synuclein. Post-translational modifications of α-synuclein induced b...
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| Veröffentlicht in: | ACS chemical neuroscience 2019-02, Vol.10 (2), p.777-782 |
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| creator | He, Yixi Yu, Zhongwang Chen, Shengdi |
| description | Parkinson’s disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which are primarily composed of α-synuclein. Post-translational modifications of α-synuclein induced by nitrative stress have been linked to neurodegeneration. Here, we review the concept of α-synuclein nitration and its biological consequences. We also discuss the pathological roles of nitrated α-synuclein and their potential clinical implications in Parkinson’s disease. |
| doi_str_mv | 10.1021/acschemneuro.8b00288 |
| format | Article |
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Post-translational modifications of α-synuclein induced by nitrative stress have been linked to neurodegeneration. Here, we review the concept of α-synuclein nitration and its biological consequences. We also discuss the pathological roles of nitrated α-synuclein and their potential clinical implications in Parkinson’s disease.</description><identifier>ISSN: 1948-7193</identifier><identifier>EISSN: 1948-7193</identifier><identifier>DOI: 10.1021/acschemneuro.8b00288</identifier><identifier>PMID: 30183251</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>alpha-Synuclein - metabolism ; Animals ; Brain - metabolism ; Brain - pathology ; Humans ; Nitrosative Stress - physiology ; Parkinson Disease - metabolism ; Parkinson Disease - pathology ; Protein Aggregates - physiology</subject><ispartof>ACS chemical neuroscience, 2019-02, Vol.10 (2), p.777-782</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a414t-9a3db6e3f997f9a8cfb002a5b709f33e103e57f3a896064a00865c91288618583</citedby><cites>FETCH-LOGICAL-a414t-9a3db6e3f997f9a8cfb002a5b709f33e103e57f3a896064a00865c91288618583</cites><orcidid>0000-0002-8212-0158</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acschemneuro.8b00288$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acschemneuro.8b00288$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30183251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Yixi</creatorcontrib><creatorcontrib>Yu, Zhongwang</creatorcontrib><creatorcontrib>Chen, Shengdi</creatorcontrib><title>Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease</title><title>ACS chemical neuroscience</title><addtitle>ACS Chem. 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We also discuss the pathological roles of nitrated α-synuclein and their potential clinical implications in Parkinson’s disease.</description><subject>alpha-Synuclein - metabolism</subject><subject>Animals</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Humans</subject><subject>Nitrosative Stress - physiology</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson Disease - pathology</subject><subject>Protein Aggregates - physiology</subject><issn>1948-7193</issn><issn>1948-7193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1OwzAQhS0EoqVwA4SyZJMyjvNjL6sCpRICJGBtOa6juiR2sJNFd1yD63ESXFpQV6xmNPrezJuH0DmGMYYEXwnp5VI1RvXOjmkJkFB6gIaYpTQuMCOHe_0AnXi_AsgZ0PwYDQhgSpIMD9FsUrdLET-vTS9rpU30oDsnOm1NJMwimnc-mjdtreXPzEeBeBLuTRtvzdfHp4-utVfCq1N0VInaq7NdHaHX25uX6V18_zibTyf3sUhx2sVMkEWZK1IxVlRMUFltjIusLIBVhCgMRGVFRQRlOeSpgOA3kwyH33JMM0pG6HK7t3X2vVe-4432UtW1MMr2nicYgCQ5LnBA0y0qnfXeqYq3TjfCrTkGvomQ70fIdxEG2cXuQl82avEn-s0sALAFgpyvbO9MePj_nd9g34Dy</recordid><startdate>20190220</startdate><enddate>20190220</enddate><creator>He, Yixi</creator><creator>Yu, Zhongwang</creator><creator>Chen, Shengdi</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8212-0158</orcidid></search><sort><creationdate>20190220</creationdate><title>Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease</title><author>He, Yixi ; Yu, Zhongwang ; Chen, Shengdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a414t-9a3db6e3f997f9a8cfb002a5b709f33e103e57f3a896064a00865c91288618583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>alpha-Synuclein - metabolism</topic><topic>Animals</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Humans</topic><topic>Nitrosative Stress - physiology</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson Disease - pathology</topic><topic>Protein Aggregates - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Yixi</creatorcontrib><creatorcontrib>Yu, Zhongwang</creatorcontrib><creatorcontrib>Chen, Shengdi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS chemical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Yixi</au><au>Yu, Zhongwang</au><au>Chen, Shengdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease</atitle><jtitle>ACS chemical neuroscience</jtitle><addtitle>ACS Chem. Neurosci</addtitle><date>2019-02-20</date><risdate>2019</risdate><volume>10</volume><issue>2</issue><spage>777</spage><epage>782</epage><pages>777-782</pages><issn>1948-7193</issn><eissn>1948-7193</eissn><abstract>Parkinson’s disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which are primarily composed of α-synuclein. Post-translational modifications of α-synuclein induced by nitrative stress have been linked to neurodegeneration. Here, we review the concept of α-synuclein nitration and its biological consequences. 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| ispartof | ACS chemical neuroscience, 2019-02, Vol.10 (2), p.777-782 |
| issn | 1948-7193 1948-7193 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | alpha-Synuclein - metabolism Animals Brain - metabolism Brain - pathology Humans Nitrosative Stress - physiology Parkinson Disease - metabolism Parkinson Disease - pathology Protein Aggregates - physiology |
| title | Alpha-Synuclein Nitration and Its Implications in Parkinson’s Disease |
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