A new antitrypanosomal alkaloid from the Red Sea marine sponge Hyrtios sp

The antitrypanosomally active crude extract of the sponge Hyrtios sp. was subjected to metabolomic analysis using liquid chromatography coupled with high resolution electrospray ionization mass spectrometry (LC–HR-ESIMS) for dereplication purposes. As a result, a new alkaloid, hyrtiodoline A ( 1 ),...

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Veröffentlicht in:	Journal of antibiotics 2018-12, Vol.71 (12), p.1036-1039
Hauptverfasser:	Shady, Nourhan Hisham, Fouad, Mostafa A., Ahmed, Safwat, Pimentel-Elardo, Sheila Marie, Nodwell, Justin R., Kamel, Mohamed Salah, Abdelmohsen, Usama Ramadan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 631/92 Animals Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Brief Communication Cell Survival - drug effects Indian Ocean Ionization Ions Life Sciences Liquid chromatography Macrophages - drug effects Magnetic Resonance Spectroscopy Mass spectrometry Medicinal Chemistry Mice Microbiology NMR Nuclear magnetic resonance Organic Chemistry Porifera - chemistry Scientific imaging Spectrometry, Mass, Electrospray Ionization Trypanocidal Agents - isolation & purification Trypanocidal Agents - pharmacology Trypanosoma brucei brucei - drug effects
Online-Zugang:	Volltext
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