Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle
Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections, since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/PD) integration of in...
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| Veröffentlicht in: | Veterinary research communications 2008-10, Vol.32 (7), p.509-519 |
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| creator | Baroni, Eduardo E Díaz, Diego C Picco, Eduardo Waxman, Samanta Rodríguez, Casilda San Andrés, Manuel I Boggio, Juan C |
| description | Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections, since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/PD) integration of intravenous sulfamethazine (60 mg/kgbw) in cattle, and the possible therapeutic outcomes. Six healthy female calves, at the age of one, three, seven and fifteen weeks were used. Normality analysis was assessed with the Shapiro-Wilk test. Non-parametric tests for paired data were used. Plasma concentrations were quantified using HPLC/uv. Differences were found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area under the concentration-time curve and elimination half-life) and in the PK/PD integration. The ratios obtained in PK/PD integration (T>MIC, WAUC) confirm that it is necessary to apply twice the dose of sulfamethazine in >= 7 weeks-old cattle to reach a satisfactory dosage regimen (MIC >= 32 μg/mL). |
| doi_str_mv | 10.1007/s11259-008-9053-y |
| format | Article |
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The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/PD) integration of intravenous sulfamethazine (60 mg/kgbw) in cattle, and the possible therapeutic outcomes. Six healthy female calves, at the age of one, three, seven and fifteen weeks were used. Normality analysis was assessed with the Shapiro-Wilk test. Non-parametric tests for paired data were used. Plasma concentrations were quantified using HPLC/uv. Differences were found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area under the concentration-time curve and elimination half-life) and in the PK/PD integration. The ratios obtained in PK/PD integration (T>MIC, WAUC) confirm that it is necessary to apply twice the dose of sulfamethazine in >= 7 weeks-old cattle to reach a satisfactory dosage regimen (MIC >= 32 μg/mL).</description><identifier>ISSN: 0165-7380</identifier><identifier>EISSN: 1573-7446</identifier><identifier>DOI: 10.1007/s11259-008-9053-y</identifier><identifier>PMID: 18481189</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : Springer Netherlands</publisher><subject>Aging - physiology ; animal age ; Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - blood ; Anti-Bacterial Agents - pharmacokinetics ; Area Under Curve ; Biomedical and Life Sciences ; blood chemistry ; calves ; Cattle ; dosage ; dose response ; Dose-Response Relationship, Drug ; Female ; Half-Life ; Holstein ; Injections, Intravenous ; intravenous injection ; Life Sciences ; Microbial Sensitivity Tests ; Original Article ; pharmacokinetics ; sulfamethazine ; Sulfamethazine - administration & dosage ; Sulfamethazine - blood ; Sulfamethazine - pharmacokinetics ; sulfonamides ; temporal variation ; Veterinary Medicine/Veterinary Science ; Zoology</subject><ispartof>Veterinary research communications, 2008-10, Vol.32 (7), p.509-519</ispartof><rights>Springer Science+Business Media B.V. 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-e049661a7318b71d02dde0dfb23fdc3f8fe0a1ed0deb5c126ef39e18010f7ca33</citedby><cites>FETCH-LOGICAL-c455t-e049661a7318b71d02dde0dfb23fdc3f8fe0a1ed0deb5c126ef39e18010f7ca33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11259-008-9053-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11259-008-9053-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18481189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baroni, Eduardo E</creatorcontrib><creatorcontrib>Díaz, Diego C</creatorcontrib><creatorcontrib>Picco, Eduardo</creatorcontrib><creatorcontrib>Waxman, Samanta</creatorcontrib><creatorcontrib>Rodríguez, Casilda</creatorcontrib><creatorcontrib>San Andrés, Manuel I</creatorcontrib><creatorcontrib>Boggio, Juan C</creatorcontrib><title>Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><addtitle>Vet Res Commun</addtitle><description>Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections, since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/PD) integration of intravenous sulfamethazine (60 mg/kgbw) in cattle, and the possible therapeutic outcomes. Six healthy female calves, at the age of one, three, seven and fifteen weeks were used. Normality analysis was assessed with the Shapiro-Wilk test. Non-parametric tests for paired data were used. Plasma concentrations were quantified using HPLC/uv. Differences were found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area under the concentration-time curve and elimination half-life) and in the PK/PD integration. The ratios obtained in PK/PD integration (T>MIC, WAUC) confirm that it is necessary to apply twice the dose of sulfamethazine in >= 7 weeks-old cattle to reach a satisfactory dosage regimen (MIC >= 32 μg/mL).</description><subject>Aging - physiology</subject><subject>animal age</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Area Under Curve</subject><subject>Biomedical and Life Sciences</subject><subject>blood chemistry</subject><subject>calves</subject><subject>Cattle</subject><subject>dosage</subject><subject>dose response</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Half-Life</subject><subject>Holstein</subject><subject>Injections, Intravenous</subject><subject>intravenous injection</subject><subject>Life Sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Original Article</subject><subject>pharmacokinetics</subject><subject>sulfamethazine</subject><subject>Sulfamethazine - administration & dosage</subject><subject>Sulfamethazine - blood</subject><subject>Sulfamethazine - pharmacokinetics</subject><subject>sulfonamides</subject><subject>temporal variation</subject><subject>Veterinary Medicine/Veterinary Science</subject><subject>Zoology</subject><issn>0165-7380</issn><issn>1573-7446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1v1DAQhi0EotvCD-ACFofeAjNxHMdHVJUPqRIH6NnyJuNdl8RZbKfS8utxyUqVOMDJkud5X4_1MPYK4R0CqPcJsZa6AugqDVJUxydsg1KJSjVN-5RtAFtZKdHBGTtP6Q4AdAfiOTvDrukQO71h87Vz1OfEZ8ftjvgceN4TP-xtnGw___CBsu__jJMPu5H4MCfiaRmdnSjv7a9CcOsyRe5DjvaewrwkbofJB5_KRfal0wfe25xHesGeOTsmenk6L9jtx-vvV5-rm6-fvlx9uKn6RspcETS6bdEqgd1W4QD1MBAMblsLN_TCdY7AIg0w0Fb2WLfkhCbsAMGp3gpxwS7X3kOcfy6Uspl86mkcbaCyn6lB6xZE818QtWxbJbGAb_8C7-YlhvIJU6tGo9RNWyBcoT7OKUVy5hD9ZOPRIJgHZ2Z1Zooz8-DMHEvm9al42U40PCZOkgpQr0Aqo7Cj-Pjyv1rfrCFnZ2N30Sdz-60GFICyAdkp8RuJ0K11</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Baroni, Eduardo E</creator><creator>Díaz, Diego C</creator><creator>Picco, Eduardo</creator><creator>Waxman, Samanta</creator><creator>Rodríguez, Casilda</creator><creator>San Andrés, Manuel I</creator><creator>Boggio, Juan C</creator><general>Dordrecht : Springer Netherlands</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20081001</creationdate><title>Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle</title><author>Baroni, Eduardo E ; Díaz, Diego C ; Picco, Eduardo ; Waxman, Samanta ; Rodríguez, Casilda ; San Andrés, Manuel I ; Boggio, Juan C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-e049661a7318b71d02dde0dfb23fdc3f8fe0a1ed0deb5c126ef39e18010f7ca33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aging - physiology</topic><topic>animal age</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Area Under Curve</topic><topic>Biomedical and Life Sciences</topic><topic>blood chemistry</topic><topic>calves</topic><topic>Cattle</topic><topic>dosage</topic><topic>dose response</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Half-Life</topic><topic>Holstein</topic><topic>Injections, Intravenous</topic><topic>intravenous injection</topic><topic>Life Sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Original Article</topic><topic>pharmacokinetics</topic><topic>sulfamethazine</topic><topic>Sulfamethazine - administration & dosage</topic><topic>Sulfamethazine - blood</topic><topic>Sulfamethazine - pharmacokinetics</topic><topic>sulfonamides</topic><topic>temporal variation</topic><topic>Veterinary Medicine/Veterinary Science</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baroni, Eduardo E</creatorcontrib><creatorcontrib>Díaz, Diego C</creatorcontrib><creatorcontrib>Picco, Eduardo</creatorcontrib><creatorcontrib>Waxman, Samanta</creatorcontrib><creatorcontrib>Rodríguez, Casilda</creatorcontrib><creatorcontrib>San Andrés, Manuel I</creatorcontrib><creatorcontrib>Boggio, Juan C</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Veterinary research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baroni, Eduardo E</au><au>Díaz, Diego C</au><au>Picco, Eduardo</au><au>Waxman, Samanta</au><au>Rodríguez, Casilda</au><au>San Andrés, Manuel I</au><au>Boggio, Juan C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle</atitle><jtitle>Veterinary research communications</jtitle><stitle>Vet Res Commun</stitle><addtitle>Vet Res Commun</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>32</volume><issue>7</issue><spage>509</spage><epage>519</epage><pages>509-519</pages><issn>0165-7380</issn><eissn>1573-7446</eissn><abstract>Sulphonamides are still being used widely, influenced by the low cost and the efficacy against many common bacterial infections, since they present a broad spectrum of activity. The aim of this study was to determine the effect of age on the pharmacokinetic/pharmacodynamics (PK/PD) integration of intravenous sulfamethazine (60 mg/kgbw) in cattle, and the possible therapeutic outcomes. Six healthy female calves, at the age of one, three, seven and fifteen weeks were used. Normality analysis was assessed with the Shapiro-Wilk test. Non-parametric tests for paired data were used. Plasma concentrations were quantified using HPLC/uv. Differences were found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area under the concentration-time curve and elimination half-life) and in the PK/PD integration. The ratios obtained in PK/PD integration (T>MIC, WAUC) confirm that it is necessary to apply twice the dose of sulfamethazine in >= 7 weeks-old cattle to reach a satisfactory dosage regimen (MIC >= 32 μg/mL).</abstract><cop>Dordrecht</cop><pub>Dordrecht : Springer Netherlands</pub><pmid>18481189</pmid><doi>10.1007/s11259-008-9053-y</doi><tpages>11</tpages></addata></record> |
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| subjects | Aging - physiology animal age Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Area Under Curve Biomedical and Life Sciences blood chemistry calves Cattle dosage dose response Dose-Response Relationship, Drug Female Half-Life Holstein Injections, Intravenous intravenous injection Life Sciences Microbial Sensitivity Tests Original Article pharmacokinetics sulfamethazine Sulfamethazine - administration & dosage Sulfamethazine - blood Sulfamethazine - pharmacokinetics sulfonamides temporal variation Veterinary Medicine/Veterinary Science Zoology |
| title | Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle |
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