Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes

Preferential utilization of fatty acids for ATP production represents an advanced metabolic phenotype in developing cardiomyocytes. We investigated whether this phenotype could be attained in human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) and assessed its influence on mitocho...

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Veröffentlicht in:	International journal of cardiology 2018-12, Vol.272, p.288-297
Hauptverfasser:	Ramachandra, Chrishan J.A., Mehta, Ashish, Wong, Philip, Ja, K.P. Myu Mai, Fritsche-Danielson, Regina, Bhat, Ratan V., Hausenloy, Derek J., Kovalik, Jean-Paul, Shim, Winston
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioenergetics Cardiomyocytes Cells, Cultured Energy Metabolism - physiology Fatty Acids - metabolism Human induced pluripotent stem cells Humans Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - ultrastructure Lipid Metabolism - physiology Metabolism Mitochondria Mitochondria - metabolism Mitochondria - ultrastructure Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Phenotype T-tubules
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