Discovery of novel vinyl sulfone derivatives as anti-tumor agents with microtubule polymerization inhibitory and vascular disrupting activities

Vinyl sulfone or sulfoxide moieties were firstly introduced to the structure of chalcone compound by replacing the carbonyl group to afford a series of novel compounds as potential anti-tubulin agents. All of the target compounds were evaluated for their anti-proliferative activity. Among them, comp...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-09, Vol.157, p.1068-1080
Hauptverfasser:	Li, Wenlong, Yin, Ying, Yao, Hong, Shuai, Wen, Sun, Honghao, Xu, Shengtao, Liu, Jie, Yao, Hequan, Zhu, Zheying, Xu, Jinyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-tumor activity Colchicine binding site Tubulin inhibitors Vinyl sulfone
Online-Zugang:	Volltext
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