Fowl adenovirus serotype 4-induced apoptosis, autophagy, and a severe inflammatory response in liver

•Fowl adenovirus serotype 4 (FAdV-4) is a hepatotrophic virus that causes severe liver diseases.•FAdV-4 impaired liver integrity and function.•FAdV-4 induced hepatocyte apoptosis and autophagy in a time-dependent manner in vivo and in vitro.•FAdV-4 induced liver injury by via a severe inflammatory r...

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Veröffentlicht in:	Veterinary microbiology 2018-09, Vol.223, p.34-41
Hauptverfasser:	Niu, Yujuan, Sun, Qinqin, Zhang, Guihua, Liu, Xingpo, Shang, Yingli, Xiao, Yihong, Liu, Sidang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Infections - pathology Adenoviridae Infections - veterinary Adenoviridae Infections - virology Adenoviruses Animals Apoptosis Aspartate aminotransferase Autophagy Aviadenovirus - immunology Aviadenovirus - physiology Cell death Chickens - immunology Chickens - virology FAdV-4 Hepatocytes Inclusion bodies Inflammation Inflammation - veterinary Inflammatory response Interleukin 6 Interleukin 8 L-Lactate dehydrogenase Lactic acid Liver Liver - physiopathology Liver - virology Liver diseases Liver injury Metastases Molecular modelling mRNA Phagocytosis Poultry Diseases - pathology Poultry Diseases - virology Serogroup Specific Pathogen-Free Organisms Statistical analysis Tumor necrosis factor-α Viruses
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