Identification of naringin metabolites mediated by human intestinal microbes with stable isotope-labeling method and UFLC-Q-TOF-MS/MS

•A total of 13 naringin metabolites mediated by human intestinal microbes were identified, among which 5 were reported for the first time.•Naringin underwent extensive phase I metabolism in human intestinal microbes.•Microbial metabolic profiles of naringin among different human individuals were div...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2018-11, Vol.161, p.262-272
Hauptverfasser:	Chen, Taobin, Su, Weiwei, Yan, Zenghao, Wu, Hao, Zeng, Xuan, Peng, Wei, Gan, Li, Zhang, Yaohui, Yao, Hongliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid - methods Flavanones - pharmacokinetics Gastrointestinal Microbiome Human intestinal microbe Humans Isotope Labeling - methods Metabolic Detoxication, Phase I Metabolite Naringin Stable isotope-labeling Tandem Mass Spectrometry - methods UFLC-Q-TOF-MS/MS
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