Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy
Skeletal muscle dysfunction and poor functional capacity are important extra-pulmonary manifestations of chronic obstructive pulmonary disease (COPD), especially in COPD patients on long-term O2 therapy (LTOT). Beside the role of pulmonary rehabilitation, the effect of nutritional interventions is s...
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| Veröffentlicht in: | Respiratory medicine 2018-09, Vol.142, p.86-93 |
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| creator | De Benedetto, Fernando Pastorelli, Roberta Ferrario, Manuela de Blasio, Francesca Marinari, Stefano Brunelli, Laura Wouters, Emiel F.M. Polverino, Francesca Celli, Bartolome R. |
| description | Skeletal muscle dysfunction and poor functional capacity are important extra-pulmonary manifestations of chronic obstructive pulmonary disease (COPD), especially in COPD patients on long-term O2 therapy (LTOT). Beside the role of pulmonary rehabilitation, the effect of nutritional interventions is still controversial, and there are knowledge gaps on the effective role of nutraceutical supplementation on hard endpoints. The aim of this study was to investigate the effects of nutritional supplementation with Coenzyme Q10 (QTer®) – a powerful antioxidant with the potential to reduce oxidative stress and improve mitochondrial function − and Creatine on functional, nutritional, and metabolomic profile in COPD patients on long-term O2 therapy.
One-hundred and eight patients with COPD from 9 Italian hospitals were enrolled in this double-blinded randomized placebo-controlled clinical study. At baseline and after 2 months of therapy, the patients underwent spirometry, 6-minute walk test (6MWT), bioelectrical impedance analysis, and activities of daily living questionnaire (ADL). Also, dyspnea scores and BODE index were calculated. At both time points, plasma concentration of CoQ10 and metabolomic profiling were measured.
Ninety patients, who randomly received supplementation with QTer® and Creatine or placebo, completed the study. Compared with placebo, supplemented patients showed improvements in 6MWT (51 ± 69 versus 15 ± 91 m, p |
| doi_str_mv | 10.1016/j.rmed.2018.08.002 |
| format | Article |
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One-hundred and eight patients with COPD from 9 Italian hospitals were enrolled in this double-blinded randomized placebo-controlled clinical study. At baseline and after 2 months of therapy, the patients underwent spirometry, 6-minute walk test (6MWT), bioelectrical impedance analysis, and activities of daily living questionnaire (ADL). Also, dyspnea scores and BODE index were calculated. At both time points, plasma concentration of CoQ10 and metabolomic profiling were measured.
Ninety patients, who randomly received supplementation with QTer® and Creatine or placebo, completed the study. Compared with placebo, supplemented patients showed improvements in 6MWT (51 ± 69 versus 15 ± 91 m, p < 0.05), body cell mass and phase angle, sodium/potassium ratio, dyspnea indices and ADL score. The CoQ10 plasma concentration increased in the supplementation group whereas it did not change in the placebo group. The metabolomics profile also differed between groups. Adverse events were similar in both groups.
These results show that in patients with COPD, dietary supplementation with CoQ10 and Creatine improves functional performance, body composition and perception of dyspnea. A systemic increase in some anti-inflammatory metabolites supports a pathobiological mechanism as a reason for these benefits. Further trials should help clarifying the role of QTer® and Creatine supplementation in patients with COPD.
•Qter® and Creatine improve 6MWT, body composition, dyspnea and daily activities.•At 2 months, only 11% of Active patients worsened their 6MWT vs 29% of the Placebos.•Qter® and Creatine increase anti-inflammatory metabolites, improving metabolomics profile.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2018.08.002</identifier><identifier>PMID: 30170808</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>6-Minute walk test ; Activities of Daily Living ; Adenosine ; Aged ; Aged, 80 and over ; Antioxidants ; Antioxidants - administration & dosage ; Bioelectricity ; Bioimpedance ; Body Composition ; Body mass index ; Chronic obstructive pulmonary disease ; Clinical trials ; Coenzime Q10 ; Coenzyme Q10 ; COPD ; Creatine ; Creatine - administration & dosage ; Dietary Supplements ; Double-Blind Method ; Dyspnea ; Female ; Functional foods & nutraceuticals ; Humans ; Inflammation ; Lung diseases ; Male ; Malnutrition ; Metabolites ; Metabolomics ; Middle Aged ; Mitochondria ; Muscles ; Musculoskeletal system ; Obstructive lung disease ; Oxidative stress ; Oxygen Inhalation Therapy ; Oxygen therapy ; Patients ; Physical Functional Performance ; Potassium ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Disease, Chronic Obstructive - therapy ; Rehabilitation ; Respiration ; Skeletal muscle ; Sodium ; Therapy ; Time Factors ; Ubiquinone - administration & dosage ; Ubiquinone - analogs & derivatives ; Walk Test</subject><ispartof>Respiratory medicine, 2018-09, Vol.142, p.86-93</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Ltd.</rights><rights>Copyright Elsevier Limited Sep 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-5fe7766c454b16b3109753a6159e760164801f9bfbc1f4a7d6e9c9afaecdcc0f3</citedby><cites>FETCH-LOGICAL-c428t-5fe7766c454b16b3109753a6159e760164801f9bfbc1f4a7d6e9c9afaecdcc0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0954611118302592$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30170808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Benedetto, Fernando</creatorcontrib><creatorcontrib>Pastorelli, Roberta</creatorcontrib><creatorcontrib>Ferrario, Manuela</creatorcontrib><creatorcontrib>de Blasio, Francesca</creatorcontrib><creatorcontrib>Marinari, Stefano</creatorcontrib><creatorcontrib>Brunelli, Laura</creatorcontrib><creatorcontrib>Wouters, Emiel F.M.</creatorcontrib><creatorcontrib>Polverino, Francesca</creatorcontrib><creatorcontrib>Celli, Bartolome R.</creatorcontrib><creatorcontrib>Interdisciplinary Association for Research in Lung Disease (AIMAR) Study Group</creatorcontrib><title>Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Skeletal muscle dysfunction and poor functional capacity are important extra-pulmonary manifestations of chronic obstructive pulmonary disease (COPD), especially in COPD patients on long-term O2 therapy (LTOT). Beside the role of pulmonary rehabilitation, the effect of nutritional interventions is still controversial, and there are knowledge gaps on the effective role of nutraceutical supplementation on hard endpoints. The aim of this study was to investigate the effects of nutritional supplementation with Coenzyme Q10 (QTer®) – a powerful antioxidant with the potential to reduce oxidative stress and improve mitochondrial function − and Creatine on functional, nutritional, and metabolomic profile in COPD patients on long-term O2 therapy.
One-hundred and eight patients with COPD from 9 Italian hospitals were enrolled in this double-blinded randomized placebo-controlled clinical study. At baseline and after 2 months of therapy, the patients underwent spirometry, 6-minute walk test (6MWT), bioelectrical impedance analysis, and activities of daily living questionnaire (ADL). Also, dyspnea scores and BODE index were calculated. At both time points, plasma concentration of CoQ10 and metabolomic profiling were measured.
Ninety patients, who randomly received supplementation with QTer® and Creatine or placebo, completed the study. Compared with placebo, supplemented patients showed improvements in 6MWT (51 ± 69 versus 15 ± 91 m, p < 0.05), body cell mass and phase angle, sodium/potassium ratio, dyspnea indices and ADL score. The CoQ10 plasma concentration increased in the supplementation group whereas it did not change in the placebo group. The metabolomics profile also differed between groups. Adverse events were similar in both groups.
These results show that in patients with COPD, dietary supplementation with CoQ10 and Creatine improves functional performance, body composition and perception of dyspnea. A systemic increase in some anti-inflammatory metabolites supports a pathobiological mechanism as a reason for these benefits. Further trials should help clarifying the role of QTer® and Creatine supplementation in patients with COPD.
•Qter® and Creatine improve 6MWT, body composition, dyspnea and daily activities.•At 2 months, only 11% of Active patients worsened their 6MWT vs 29% of the Placebos.•Qter® and Creatine increase anti-inflammatory metabolites, improving metabolomics profile.</description><subject>6-Minute walk test</subject><subject>Activities of Daily Living</subject><subject>Adenosine</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Bioelectricity</subject><subject>Bioimpedance</subject><subject>Body Composition</subject><subject>Body mass index</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Clinical trials</subject><subject>Coenzime Q10</subject><subject>Coenzyme Q10</subject><subject>COPD</subject><subject>Creatine</subject><subject>Creatine - administration & dosage</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Dyspnea</subject><subject>Female</subject><subject>Functional foods & nutraceuticals</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Middle Aged</subject><subject>Mitochondria</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Obstructive lung disease</subject><subject>Oxidative stress</subject><subject>Oxygen Inhalation Therapy</subject><subject>Oxygen therapy</subject><subject>Patients</subject><subject>Physical Functional Performance</subject><subject>Potassium</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Disease, Chronic Obstructive - therapy</subject><subject>Rehabilitation</subject><subject>Respiration</subject><subject>Skeletal muscle</subject><subject>Sodium</subject><subject>Therapy</subject><subject>Time Factors</subject><subject>Ubiquinone - administration & dosage</subject><subject>Ubiquinone - analogs & derivatives</subject><subject>Walk Test</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS1ERYfCC7BAltiwyfTacZxYYoOGX6lSi4C15TjXbUaJHeykMC_FQ_BkdZh2wwLpSl6c7x75nkPICwZbBkye77dxxG7LgTVbyAP8EdmwquRFCVI8JhtQlSgkY-yUPE1pDwBKCHhCTktgNTTQbMjydZmmAUf0s5n74OnPfr6hX2aMf35T4zu6i5gFj7QfpxhuMVG3eLuiZqATRhfiaLzNuqe7y6t3dMp4dks0mw3BX9PsNdLw63CNns43GM10eEZOnBkSPr9_z8j3D--_7T4VF5cfP-_eXhRW8GYuKod1LaUVlWiZbEsGqq5KI1mlsJY5AtEAc6p1rWVOmLqTqKwyzqDtrAVXnpHXR9_89R8LplmPfbI4DMZjWJLmoJq6LjkXGX31D7oPS8xH_qUqwRRvykzxI2VjSCmi01PsRxMPmoFeS9F7vZai11I05AGel17eWy_tqj2sPLSQgTdHAHMWtz1GnWzO0GLXR7Sz7kL_P_87lCSfpQ</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>De Benedetto, Fernando</creator><creator>Pastorelli, Roberta</creator><creator>Ferrario, Manuela</creator><creator>de Blasio, Francesca</creator><creator>Marinari, Stefano</creator><creator>Brunelli, Laura</creator><creator>Wouters, Emiel F.M.</creator><creator>Polverino, Francesca</creator><creator>Celli, Bartolome R.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201809</creationdate><title>Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy</title><author>De Benedetto, Fernando ; Pastorelli, Roberta ; Ferrario, Manuela ; de Blasio, Francesca ; Marinari, Stefano ; Brunelli, Laura ; Wouters, Emiel F.M. ; Polverino, Francesca ; Celli, Bartolome R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-5fe7766c454b16b3109753a6159e760164801f9bfbc1f4a7d6e9c9afaecdcc0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>6-Minute walk test</topic><topic>Activities of Daily Living</topic><topic>Adenosine</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Bioelectricity</topic><topic>Bioimpedance</topic><topic>Body Composition</topic><topic>Body mass index</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Clinical trials</topic><topic>Coenzime Q10</topic><topic>Coenzyme Q10</topic><topic>COPD</topic><topic>Creatine</topic><topic>Creatine - administration & dosage</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Dyspnea</topic><topic>Female</topic><topic>Functional foods & nutraceuticals</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Middle Aged</topic><topic>Mitochondria</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Obstructive lung disease</topic><topic>Oxidative stress</topic><topic>Oxygen Inhalation Therapy</topic><topic>Oxygen therapy</topic><topic>Patients</topic><topic>Physical Functional Performance</topic><topic>Potassium</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary Disease, Chronic Obstructive - therapy</topic><topic>Rehabilitation</topic><topic>Respiration</topic><topic>Skeletal muscle</topic><topic>Sodium</topic><topic>Therapy</topic><topic>Time Factors</topic><topic>Ubiquinone - administration & dosage</topic><topic>Ubiquinone - analogs & derivatives</topic><topic>Walk Test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Benedetto, Fernando</creatorcontrib><creatorcontrib>Pastorelli, Roberta</creatorcontrib><creatorcontrib>Ferrario, Manuela</creatorcontrib><creatorcontrib>de Blasio, Francesca</creatorcontrib><creatorcontrib>Marinari, Stefano</creatorcontrib><creatorcontrib>Brunelli, Laura</creatorcontrib><creatorcontrib>Wouters, Emiel F.M.</creatorcontrib><creatorcontrib>Polverino, Francesca</creatorcontrib><creatorcontrib>Celli, Bartolome R.</creatorcontrib><creatorcontrib>Interdisciplinary Association for Research in Lung Disease (AIMAR) Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Benedetto, Fernando</au><au>Pastorelli, Roberta</au><au>Ferrario, Manuela</au><au>de Blasio, Francesca</au><au>Marinari, Stefano</au><au>Brunelli, Laura</au><au>Wouters, Emiel F.M.</au><au>Polverino, Francesca</au><au>Celli, Bartolome R.</au><aucorp>Interdisciplinary Association for Research in Lung Disease (AIMAR) Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2018-09</date><risdate>2018</risdate><volume>142</volume><spage>86</spage><epage>93</epage><pages>86-93</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Skeletal muscle dysfunction and poor functional capacity are important extra-pulmonary manifestations of chronic obstructive pulmonary disease (COPD), especially in COPD patients on long-term O2 therapy (LTOT). Beside the role of pulmonary rehabilitation, the effect of nutritional interventions is still controversial, and there are knowledge gaps on the effective role of nutraceutical supplementation on hard endpoints. The aim of this study was to investigate the effects of nutritional supplementation with Coenzyme Q10 (QTer®) – a powerful antioxidant with the potential to reduce oxidative stress and improve mitochondrial function − and Creatine on functional, nutritional, and metabolomic profile in COPD patients on long-term O2 therapy.
One-hundred and eight patients with COPD from 9 Italian hospitals were enrolled in this double-blinded randomized placebo-controlled clinical study. At baseline and after 2 months of therapy, the patients underwent spirometry, 6-minute walk test (6MWT), bioelectrical impedance analysis, and activities of daily living questionnaire (ADL). Also, dyspnea scores and BODE index were calculated. At both time points, plasma concentration of CoQ10 and metabolomic profiling were measured.
Ninety patients, who randomly received supplementation with QTer® and Creatine or placebo, completed the study. Compared with placebo, supplemented patients showed improvements in 6MWT (51 ± 69 versus 15 ± 91 m, p < 0.05), body cell mass and phase angle, sodium/potassium ratio, dyspnea indices and ADL score. The CoQ10 plasma concentration increased in the supplementation group whereas it did not change in the placebo group. The metabolomics profile also differed between groups. Adverse events were similar in both groups.
These results show that in patients with COPD, dietary supplementation with CoQ10 and Creatine improves functional performance, body composition and perception of dyspnea. A systemic increase in some anti-inflammatory metabolites supports a pathobiological mechanism as a reason for these benefits. Further trials should help clarifying the role of QTer® and Creatine supplementation in patients with COPD.
•Qter® and Creatine improve 6MWT, body composition, dyspnea and daily activities.•At 2 months, only 11% of Active patients worsened their 6MWT vs 29% of the Placebos.•Qter® and Creatine increase anti-inflammatory metabolites, improving metabolomics profile.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30170808</pmid><doi>10.1016/j.rmed.2018.08.002</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 6-Minute walk test Activities of Daily Living Adenosine Aged Aged, 80 and over Antioxidants Antioxidants - administration & dosage Bioelectricity Bioimpedance Body Composition Body mass index Chronic obstructive pulmonary disease Clinical trials Coenzime Q10 Coenzyme Q10 COPD Creatine Creatine - administration & dosage Dietary Supplements Double-Blind Method Dyspnea Female Functional foods & nutraceuticals Humans Inflammation Lung diseases Male Malnutrition Metabolites Metabolomics Middle Aged Mitochondria Muscles Musculoskeletal system Obstructive lung disease Oxidative stress Oxygen Inhalation Therapy Oxygen therapy Patients Physical Functional Performance Potassium Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Disease, Chronic Obstructive - therapy Rehabilitation Respiration Skeletal muscle Sodium Therapy Time Factors Ubiquinone - administration & dosage Ubiquinone - analogs & derivatives Walk Test |
| title | Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy |
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