Development of a magnetic nano-graphene oxide carrier for improved glioma-targeted drug delivery and imaging: In vitro and in vivo evaluations

To overcome the obstacles inflicted by the BBB in Glioblastoma multiforme (GBM) we investigated the use of Multifunctional nanoparticles that designed with a Nano-graphene oxide (NGO) sheet functionalized with magnetic poly (lactic-co-glycolic acid) (PLGA) and was used for glioma targeting delivery...

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Veröffentlicht in:	Chemico-biological interactions 2018-11, Vol.295, p.97-108
Hauptverfasser:	Shirvalilou, Sakine, Khoei, Samideh, Khoee, Sepideh, Raoufi, Nida Jamali, Karimi, Mohammad Reza, Shakeri-Zadeh, Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Iodo-2′-deoxyuridine Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Brain Neoplasms - diagnostic imaging Brain Neoplasms - drug therapy Brain Neoplasms - pathology Cell Proliferation - drug effects Cell Survival - drug effects Disease Models, Animal Drug Carriers - chemistry Drug Carriers - pharmacology Drug Delivery Systems Drug Screening Assays, Antitumor Glioma Glioma - diagnostic imaging Glioma - drug therapy Glioma - pathology Graphite - chemistry Graphite - pharmacology Magnetic Resonance Imaging Magnetic targeting Magnetite Nanoparticles - chemistry Male Nano-graphene oxide Optical Imaging Oxides - chemistry Oxides - pharmacology Particle Size Polylactic Acid-Polyglycolic Acid Copolymer - chemistry Polylactic Acid-Polyglycolic Acid Copolymer - pharmacology Rats Rats, Wistar Superparamagnetic iron oxide Tumor Cells, Cultured Uridine - analogs & derivatives Uridine - chemistry Uridine - pharmacology
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