Immune and metabolic shifts during neonatal development reprogram liver identity and function

[Display omitted] •Neonatal livers have very different cellular composition to adults.•Myeloid cells govern liver immune system in newborns.•Several metabolic enzymes are less expressed in newborn livers.•Weaning leads to elevation of several liver metabolic functions.•Early weaning leads to changes...

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Veröffentlicht in:	Journal of hepatology 2018-12, Vol.69 (6), p.1294-1307
Hauptverfasser:	Nakagaki, Brenda Naemi, Mafra, Kassiana, de Carvalho, Érika, Lopes, Mateus Eustáquio, Carvalho-Gontijo, Raquel, de Castro-Oliveira, Hortência Maciel, Campolina-Silva, Gabriel Henrique, de Miranda, Camila Dutra Moreira, Antunes, Maísa Mota, Silva, Ana Carolina Carvalho, Diniz, Ariane Barros, Alvarenga, Débora Moreira, Lopes, Maria Alice Freitas, de Souza Lacerda, Viviane Aparecida, Mattos, Matheus Silvério, Araújo, Alan Moreira, Vidigal, Paula Vieira Teixeira, Lima, Cristiano Xavier, Mahecha, Germán A.B., Madeira, Mila Fernandes Moreira, Fernandes, Gabriel Rocha, Nogueira, Raquel Ferraz, Moreira, Thais Garcias, David, Bruna Araújo, Rezende, Rafael Machado, Menezes, Gustavo Batista
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Animals, Newborn Babies Bacteremia Biopsy Carbohydrate metabolism Cytometry Diet Early weaning Embryos Escherichia coli Infections - immunology Female Gene expression Genetic transformation Hepatocytes Humans Immune system Immunity In vivo imaging Infant, Newborn Lipid Metabolism Liver Liver - cytology Liver - immunology Liver - metabolism Lymphocytes B Metabolic pathways Metabolism Metabolome Mice Mice, Inbred C57BL Microbiota Myeloid cells Myeloid Progenitor Cells - immunology Myeloid Progenitor Cells - physiology Neonates Newborn Nutritive Value - physiology Phagocytes - immunology Phenotypes Precursor Cells, B-Lymphoid - immunology Uterus Weaning
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