Oxidative stress mediated cytotoxicity of tin (IV) oxide (SnO2) nanoparticles in human breast cancer (MCF-7) cells

[Display omitted] •We explored the cytotoxicity mechanism of SnO2 NPs in MCF-7 cells.•SnO2 NPs induced cytotoxicity in a dose and time-dependent manner.•SnO2 NPs induced ROS and H2O2 generation along with lipid peroxidation.•SnO2 NPs weakened the antioxidant capacity of cells.•SnO2 NPs induced cytot...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2018-12, Vol.172, p.152-160
Hauptverfasser:	Ahamed, Maqusood, Akhtar, Mohd Javed, Majeed Khan, M.A., Alhadlaq, Hisham A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Antioxidants Antioxidants - metabolism Apoptosis - drug effects Biointeraction Biomedical application Breast Neoplasms - pathology Cell Survival - drug effects Cytotoxicity Female Human health Humans L-Lactate Dehydrogenase - metabolism MCF-7 Cells Nanoparticles - toxicity Nanoparticles - ultrastructure Oxidants - toxicity Oxidative Stress - drug effects Redox homeostasis SnO2nanoparticles Tin Compounds - toxicity
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