Multiple Cavernous Malformations of Brain, Chest, and Skin: A Rare Case of an Infant and Literature Review

Cerebral cavernous malformations (CCMs) are vascular malformations that account for 5%–15% of all central nervous system vascular malformations. However, multiple CCMs, which can be sporadic or familial, are rare, with a prevalence of 0.1%–0.5%. Here, we presented a rare case of sporadic multiple CCMs in an infant, which were accompanied with multiple cavernous malformations of the chest and skin. CCMs were pathologically diagnosed through the total resection of the pineal regional lesion. We also observed a spontaneous regression of the remaining lesions during a follow-up period of 2 years. To our knowledge, this is the first case of CCMs in an infant in the English-language literature. •We present a rare case of sporadic multiple CCMs in an infant accompanied by multiple CMs of the chest and skin.•The condition can be diagnosed on characteristic imaging or by pathologic changes.•Spontaneous regression of the remaining lesions was observed during a follow-up period of 2 years.•To our best knowledge, the case we presented is the first report to date.