Apoptosis‐associated speck‐like protein containing a caspase‐1 recruitment domain (ASC) contributes to osteoblast differentiation and osteogenesis

The role of apoptosis‐associated speck‐like protein containing a caspase‐1 recruitment domain (ASC) in bone healing remains to be understood. To address this issue, we investigated the requirement of inflammasome‐related genes in response to bone morphogenetic protein 7 (BMP7)‐induced osteoblast dif...

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Veröffentlicht in:	Journal of cellular physiology 2019-04, Vol.234 (4), p.4140-4153
Hauptverfasser:	Sartoretto, Suelen, Gemini‐Piperni, Sara, da Silva, Rodrigo A., Calasans, Monica D., Rucci, Nadia, Pires dos Santos, Thais M., Lima, Inayá B. C., Rossi, Alexandre M., Alves, Gutemberg, Granjeiro, José M., Teti, Anna, Zambuzzi, Willian F.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Alkaline phosphatase Animals Apoptosis ASC Biocompatibility Biomarkers Biomedical materials bone formation Bone healing Bone morphogenetic protein 7 Bone Morphogenetic Protein 7 - pharmacology CARD Signaling Adaptor Proteins - deficiency CARD Signaling Adaptor Proteins - genetics CARD Signaling Adaptor Proteins - metabolism Caspase Cell Differentiation - drug effects Defects Differentiation Disease Models, Animal Female Fracture Healing Genotypes Healing inflammasome Inflammasomes Inflammasomes - drug effects Inflammasomes - metabolism Inflammation Mediators - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout osteoblast Osteoblastogenesis Osteoblasts - drug effects Osteoblasts - metabolism Osteoblasts - pathology Osteogenesis Osteogenesis - drug effects Phenotypes Proteins Recruitment regenerative medicine Rodents Signal Transduction Tibia Tibia - metabolism Tibia - pathology Tibia - physiopathology Tibial Fractures - genetics Tibial Fractures - metabolism Tibial Fractures - pathology Tibial Fractures - physiopathology Time Factors
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