Synthesis and SAR of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as potent and selective CDK4/6 inhibitors

CDK4/6 pathway is an attractive target for development of anti-cancer drugs. Herein, we reported the design and synthesis of a series of 4,5-dihydro-1H-pyrazolo [4,3-h]quinazoline derivatives as selective CDK4/6 inhibitors. Applied with the optimizing strategy to the initial scaffold, it is found th...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-09, Vol.157, p.935-945
Hauptverfasser:	Zhao, Hui, Hu, Xiaoxia, Cao, Kai, Zhang, Yue, Zhao, Kuantao, Tang, Chunlei, Feng, Bainian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer Cell cycle Cyclin dependent kinase Kinase selectivity
Online-Zugang:	Volltext
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