Automated O2 titration improves exercise capacity in patients with hypercapnic chronic obstructive pulmonary disease: a randomised controlled cross-over trial
Automatically titrated O2 flows (FreeO2) was compared with constant O2 flow on exercise capacity, O2 saturation and risk of hyperoxia-related hypercapnia in patients with severe COPD with baseline hypercapnia and long-term oxygen therapy (LTOT). Twelve patients were enrolled in a randomised double-b...
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| Veröffentlicht in: | Thorax 2019-03, Vol.74 (3), p.298-301 |
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| creator | Vivodtzev, Isabelle L’Her, Erwan Vottero, Gabrielle Yankoff, Claire Tamisier, Renaud Maltais, François Lellouche, François Pépin, Jean-Louis |
| description | Automatically titrated O2 flows (FreeO2) was compared with constant O2 flow on exercise capacity, O2 saturation and risk of hyperoxia-related hypercapnia in patients with severe COPD with baseline hypercapnia and long-term oxygen therapy (LTOT). Twelve patients were enrolled in a randomised double-blind cross-over study to perform exercise with either FreeO2 or constant flow. Endurance time (primary outcome) and SpO2 were both significantly improved with FreeO2compared with constant flow (p |
| doi_str_mv | 10.1136/thoraxjnl-2018-211967 |
| format | Article |
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Twelve patients were enrolled in a randomised double-blind cross-over study to perform exercise with either FreeO2 or constant flow. Endurance time (primary outcome) and SpO2 were both significantly improved with FreeO2compared with constant flow (p<0.04), although pCO2 was similar in both conditions. 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Automated titration of O2 significantly and clinically improved endurance walking time in patients with severe COPD receiving LTOT, without worsening of pCO2.Trial registration numberResults , NCT01575327</description><subject>ambulatory oxygen therapy</subject><subject>Automation</subject><subject>Brief communication</subject><subject>Chronic obstructive pulmonary disease</subject><subject>copd ÀÜ mechanisms</subject><subject>Dyspnea</subject><subject>Exercise</subject><subject>Hyperoxia</subject><subject>Laboratories</subject><subject>Oxygen therapy</subject><subject>Patients</subject><subject>Physical fitness</subject><subject>Walking</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc-KFDEQxoMo7uzqIwgBL15aK-nuJO1tWfyzsLAXPYdKOs1k6E7aJL3uvIzPaoaRFTx4qir4fV9V8RHyhsF7xlrxoexjwsdDmBsOTDWcsUHIZ2THOqGalg_iOdkBdNCIVooLcpnzAQAUY_IluWiBCdHxfkd-XW8lLljcSO85Lb4kLD4G6pc1xQeXqXt0yfrsqMUVrS9H6gNdK-RCyfSnL3u6P66VwTV4S-0-xVONJpe02eIfHF23eYkB05GO1Qiz-0iRJgxjXOo8UhtDSXGeT22KOTd1caIleZxfkRcTztm9_lOvyPfPn77dfG3u7r_c3lzfNYYNTDY973pmABwHK0czWKVQKddO2Fpjuq6TajRq4hXqjcRJAoKwQ993CiccTXtF3p1969c_NpeLrqdZN88YXNyy5jAoKXrBu4q-_Qc9xC2Fep3mTDEJgxBQKThTZjnoNfmlvq8Z6FN2-ik7fcpOn7OrEvZX8uT5f81vEXSiBA</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Vivodtzev, Isabelle</creator><creator>L’Her, Erwan</creator><creator>Vottero, Gabrielle</creator><creator>Yankoff, Claire</creator><creator>Tamisier, Renaud</creator><creator>Maltais, François</creator><creator>Lellouche, François</creator><creator>Pépin, Jean-Louis</creator><general>BMJ Publishing Group Ltd and British Thoracic Society</general><general>BMJ Publishing Group LTD</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1128-6529</orcidid><orcidid>https://orcid.org/0000-0002-5201-8603</orcidid><orcidid>https://orcid.org/0000-0003-3832-2358</orcidid></search><sort><creationdate>20190301</creationdate><title>Automated O2 titration improves exercise capacity in patients with hypercapnic chronic obstructive pulmonary disease: a randomised controlled cross-over trial</title><author>Vivodtzev, Isabelle ; 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| source | Alma/SFX Local Collection |
| subjects | ambulatory oxygen therapy Automation Brief communication Chronic obstructive pulmonary disease copd ÀÜ mechanisms Dyspnea Exercise Hyperoxia Laboratories Oxygen therapy Patients Physical fitness Walking |
| title | Automated O2 titration improves exercise capacity in patients with hypercapnic chronic obstructive pulmonary disease: a randomised controlled cross-over trial |
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