Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis
Background Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long‐term follow‐up on the growth of these children is limited. Objective To systematically review the literature o...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2019-01, Vol.126 (2), p.158-166 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Bay, B Lyngsø, J Hohwü, L Kesmodel, US |
| description | Background
Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long‐term follow‐up on the growth of these children is limited.
Objective
To systematically review the literature on post‐neonatal height and weight among children conceived following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, compared with that of children born after spontaneous conception.
Search strategy
A systematic computerised literature search using the online databases PubMed, Embase, and Scopus.
Selection criteria
Cohort or case–control studies with an exposed group of singletons conceived following IVF or ICSI along with a control group of spontaneously conceived singletons.
Data collection and analysis
Studies were reviewed by at least two authors. Meta‐analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle–Ottawa Scale.
Main results
Twenty studies were included, with 13 of these eligible for meta‐analyses. The meta‐analyses compared 3972 children born after IVF/ICSI with 11 012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (MD) in weight of −160 g; 95% confidence interval (95% CI) −360, 3]. When stratifying by age of child at follow‐up, we found a significant lower weight in children aged 0–4 years conceived following IVF/ICSI treatment (MD −180 g; 95% CI −320, −4), but this was no longer significant in children from 5 years of age (MD −160 g; 95% CI −580, 260). The pooled analysis revealed no statistically significant difference in childhood height.
Conclusions
In vitro fertilisation/ICSI was not associated with long‐term weight and height.
Tweetable
Children born following IVF/ICSI do not have impaired long‐term weight or height compared with spontaneously conceived children.
Tweetable
Children born following IVF/ICSI do not have impaired long‐term weight or height compared with spontaneously conceived children. |
| doi_str_mv | 10.1111/1471-0528.15456 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2098765333</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2154486202</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4126-ef8506084c79bb47fe4450d00bd7ad2ddbde9871cfc02236508f9282cc01ae603</originalsourceid><addsrcrecordid>eNqFkb9uFDEQxi0EIuGgpkOWaGg2GXu9uz46cuKvIqWB2vLaszmfvOvD9t1pOx6BigfkSfDlQgoapvFo5vd9suYj5CWDC1bqkomOVdBwecEa0bSPyPnD5PFdDxXUXJ6RZyltAFjLoX5KzurSSS6W5-TXau28XYdg6W0Mh7ymYaDJTbcec5gSNWEy6PZo6RC8D4eyoW6ie5djoAPG7LxLOrsw0RDLJkdt5hy2XqfRGZq2GMcy3qA5Mm-ppmlOGcciMTTi3uGB6snSEbP-_eOnnrSfk0vPyZNB-4Qv7t8F-fbh_dfVp-r65uPn1bvrygjG2woH2UALUphu2feiG1CIBixAbzttubW9xaXsmBkMcF63DchhySU3BpjGFuoFeXPy3cbwfYcpq9Elg97rCcMuKQ5F3jZ1qQV5_Q-6CbtY_luocnwhy215oS5PlIkhpYiD2kY36jgrBuoYmToGpI4BqbvIiuLVve-uH9E-8H8zKkBzAg7O4_w_P3X15eZk_AcqoqSh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2154486202</pqid></control><display><type>article</type><title>Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Bay, B ; Lyngsø, J ; Hohwü, L ; Kesmodel, US</creator><creatorcontrib>Bay, B ; Lyngsø, J ; Hohwü, L ; Kesmodel, US</creatorcontrib><description>Background
Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long‐term follow‐up on the growth of these children is limited.
Objective
To systematically review the literature on post‐neonatal height and weight among children conceived following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, compared with that of children born after spontaneous conception.
Search strategy
A systematic computerised literature search using the online databases PubMed, Embase, and Scopus.
Selection criteria
Cohort or case–control studies with an exposed group of singletons conceived following IVF or ICSI along with a control group of spontaneously conceived singletons.
Data collection and analysis
Studies were reviewed by at least two authors. Meta‐analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle–Ottawa Scale.
Main results
Twenty studies were included, with 13 of these eligible for meta‐analyses. The meta‐analyses compared 3972 children born after IVF/ICSI with 11 012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (MD) in weight of −160 g; 95% confidence interval (95% CI) −360, 3]. When stratifying by age of child at follow‐up, we found a significant lower weight in children aged 0–4 years conceived following IVF/ICSI treatment (MD −180 g; 95% CI −320, −4), but this was no longer significant in children from 5 years of age (MD −160 g; 95% CI −580, 260). The pooled analysis revealed no statistically significant difference in childhood height.
Conclusions
In vitro fertilisation/ICSI was not associated with long‐term weight and height.
Tweetable
Children born following IVF/ICSI do not have impaired long‐term weight or height compared with spontaneously conceived children.
Tweetable
Children born following IVF/ICSI do not have impaired long‐term weight or height compared with spontaneously conceived children.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/1471-0528.15456</identifier><identifier>PMID: 30168249</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Assisted reproduction ; Birth weight ; Body Height ; Body Weight ; Case-Control Studies ; Child ; Child Development ; Child, Preschool ; Childhood ; Children ; Cohort Studies ; Evidence-based medicine ; Female ; Fertility ; Fertilization in Vitro - adverse effects ; height ; Humans ; In vitro fertilization ; Infant ; Infant, Newborn ; infertility ; Injection ; Meta-analysis ; Neonates ; Pregnancy ; Pregnancy Outcome ; Reproduction ; Risk Factors ; Sperm ; Sperm Injections, Intracytoplasmic - adverse effects ; Statistical analysis ; Systematic review ; weight</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2019-01, Vol.126 (2), p.158-166</ispartof><rights>2018 Royal College of Obstetricians and Gynaecologists</rights><rights>2018 Royal College of Obstetricians and Gynaecologists.</rights><rights>Copyright © 2019 Royal College of Obstetricians and Gynaecologists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4126-ef8506084c79bb47fe4450d00bd7ad2ddbde9871cfc02236508f9282cc01ae603</citedby><cites>FETCH-LOGICAL-c4126-ef8506084c79bb47fe4450d00bd7ad2ddbde9871cfc02236508f9282cc01ae603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1471-0528.15456$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1471-0528.15456$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30168249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bay, B</creatorcontrib><creatorcontrib>Lyngsø, J</creatorcontrib><creatorcontrib>Hohwü, L</creatorcontrib><creatorcontrib>Kesmodel, US</creatorcontrib><title>Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Background
Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long‐term follow‐up on the growth of these children is limited.
Objective
To systematically review the literature on post‐neonatal height and weight among children conceived following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, compared with that of children born after spontaneous conception.
Search strategy
A systematic computerised literature search using the online databases PubMed, Embase, and Scopus.
Selection criteria
Cohort or case–control studies with an exposed group of singletons conceived following IVF or ICSI along with a control group of spontaneously conceived singletons.
Data collection and analysis
Studies were reviewed by at least two authors. Meta‐analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle–Ottawa Scale.
Main results
Twenty studies were included, with 13 of these eligible for meta‐analyses. The meta‐analyses compared 3972 children born after IVF/ICSI with 11 012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (MD) in weight of −160 g; 95% confidence interval (95% CI) −360, 3]. When stratifying by age of child at follow‐up, we found a significant lower weight in children aged 0–4 years conceived following IVF/ICSI treatment (MD −180 g; 95% CI −320, −4), but this was no longer significant in children from 5 years of age (MD −160 g; 95% CI −580, 260). The pooled analysis revealed no statistically significant difference in childhood height.
Conclusions
In vitro fertilisation/ICSI was not associated with long‐term weight and height.
Tweetable
Children born following IVF/ICSI do not have impaired long‐term weight or height compared with spontaneously conceived children.
Tweetable
Children born following IVF/ICSI do not have impaired long‐term weight or height compared with spontaneously conceived children.</description><subject>Assisted reproduction</subject><subject>Birth weight</subject><subject>Body Height</subject><subject>Body Weight</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child Development</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Evidence-based medicine</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertilization in Vitro - adverse effects</subject><subject>height</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>infertility</subject><subject>Injection</subject><subject>Meta-analysis</subject><subject>Neonates</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Reproduction</subject><subject>Risk Factors</subject><subject>Sperm</subject><subject>Sperm Injections, Intracytoplasmic - adverse effects</subject><subject>Statistical analysis</subject><subject>Systematic review</subject><subject>weight</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb9uFDEQxi0EIuGgpkOWaGg2GXu9uz46cuKvIqWB2vLaszmfvOvD9t1pOx6BigfkSfDlQgoapvFo5vd9suYj5CWDC1bqkomOVdBwecEa0bSPyPnD5PFdDxXUXJ6RZyltAFjLoX5KzurSSS6W5-TXau28XYdg6W0Mh7ymYaDJTbcec5gSNWEy6PZo6RC8D4eyoW6ie5djoAPG7LxLOrsw0RDLJkdt5hy2XqfRGZq2GMcy3qA5Mm-ppmlOGcciMTTi3uGB6snSEbP-_eOnnrSfk0vPyZNB-4Qv7t8F-fbh_dfVp-r65uPn1bvrygjG2woH2UALUphu2feiG1CIBixAbzttubW9xaXsmBkMcF63DchhySU3BpjGFuoFeXPy3cbwfYcpq9Elg97rCcMuKQ5F3jZ1qQV5_Q-6CbtY_luocnwhy215oS5PlIkhpYiD2kY36jgrBuoYmToGpI4BqbvIiuLVve-uH9E-8H8zKkBzAg7O4_w_P3X15eZk_AcqoqSh</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Bay, B</creator><creator>Lyngsø, J</creator><creator>Hohwü, L</creator><creator>Kesmodel, US</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201901</creationdate><title>Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis</title><author>Bay, B ; Lyngsø, J ; Hohwü, L ; Kesmodel, US</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4126-ef8506084c79bb47fe4450d00bd7ad2ddbde9871cfc02236508f9282cc01ae603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Assisted reproduction</topic><topic>Birth weight</topic><topic>Body Height</topic><topic>Body Weight</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child Development</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children</topic><topic>Cohort Studies</topic><topic>Evidence-based medicine</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertilization in Vitro - adverse effects</topic><topic>height</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>infertility</topic><topic>Injection</topic><topic>Meta-analysis</topic><topic>Neonates</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Reproduction</topic><topic>Risk Factors</topic><topic>Sperm</topic><topic>Sperm Injections, Intracytoplasmic - adverse effects</topic><topic>Statistical analysis</topic><topic>Systematic review</topic><topic>weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bay, B</creatorcontrib><creatorcontrib>Lyngsø, J</creatorcontrib><creatorcontrib>Hohwü, L</creatorcontrib><creatorcontrib>Kesmodel, US</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bay, B</au><au>Lyngsø, J</au><au>Hohwü, L</au><au>Kesmodel, US</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2019-01</date><risdate>2019</risdate><volume>126</volume><issue>2</issue><spage>158</spage><epage>166</epage><pages>158-166</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><abstract>Background
Assisted reproductive techniques are associated with an increased risk of adverse pregnancy outcomes, including low birthweight and intrauterine growth restriction. Yet, the long‐term follow‐up on the growth of these children is limited.
Objective
To systematically review the literature on post‐neonatal height and weight among children conceived following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, compared with that of children born after spontaneous conception.
Search strategy
A systematic computerised literature search using the online databases PubMed, Embase, and Scopus.
Selection criteria
Cohort or case–control studies with an exposed group of singletons conceived following IVF or ICSI along with a control group of spontaneously conceived singletons.
Data collection and analysis
Studies were reviewed by at least two authors. Meta‐analyses were conducted using Cochrane Review Manager. The quality of the studies was assessed with the Newcastle–Ottawa Scale.
Main results
Twenty studies were included, with 13 of these eligible for meta‐analyses. The meta‐analyses compared 3972 children born after IVF/ICSI with 11 012 spontaneously conceived children and revealed no statistically significant difference in child weight [mean difference (MD) in weight of −160 g; 95% confidence interval (95% CI) −360, 3]. When stratifying by age of child at follow‐up, we found a significant lower weight in children aged 0–4 years conceived following IVF/ICSI treatment (MD −180 g; 95% CI −320, −4), but this was no longer significant in children from 5 years of age (MD −160 g; 95% CI −580, 260). The pooled analysis revealed no statistically significant difference in childhood height.
Conclusions
In vitro fertilisation/ICSI was not associated with long‐term weight and height.
Tweetable
Children born following IVF/ICSI do not have impaired long‐term weight or height compared with spontaneously conceived children.
Tweetable
Children born following IVF/ICSI do not have impaired long‐term weight or height compared with spontaneously conceived children.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30168249</pmid><doi>10.1111/1471-0528.15456</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2019-01, Vol.126 (2), p.158-166 |
| issn | 1470-0328 1471-0528 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2098765333 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Assisted reproduction Birth weight Body Height Body Weight Case-Control Studies Child Child Development Child, Preschool Childhood Children Cohort Studies Evidence-based medicine Female Fertility Fertilization in Vitro - adverse effects height Humans In vitro fertilization Infant Infant, Newborn infertility Injection Meta-analysis Neonates Pregnancy Pregnancy Outcome Reproduction Risk Factors Sperm Sperm Injections, Intracytoplasmic - adverse effects Statistical analysis Systematic review weight |
| title | Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta‐analysis |
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