Mutational Landscape of Ovarian Adult Granulosa Cell Tumors from Whole Exome and Targeted TERT Promoter Sequencing

Adult granulosa cell tumor (aGCT), the most common malignant ovarian sex cord-stromal tumor, is characterized by the forkhead transcription factor FOXL2 p.C134W somatic mutation. Late recurrences are relatively common but the molecular mechanisms of relapse or aggressive behavior are not known. The...

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Veröffentlicht in:	Molecular cancer research 2019-01, Vol.17 (1), p.177-185
Hauptverfasser:	Alexiadis, Maria, Rowley, Simone M, Chu, Simon, Leung, Dilys T H, Stewart, Colin J R, Amarasinghe, Kaushalya C, Campbell, Ian G, Fuller, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Exome Female Forkhead Box Protein L2 - genetics Gene Dosage Granulosa Cell Tumor - genetics Granulosa Cell Tumor - pathology Humans Mutation Neoplasm Staging Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Promoter Regions, Genetic Telomerase - genetics
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