Semisynthesis of ω‑Hydroxyalkylcarbonate Derivatives of Hydroxytyrosol as Antitrypanosome Agents

Several lipophilic ω-hydroxyalkylcarbonate hydroxytyrosol derivatives and also their corresponding dimeric derivatives have been synthesized, coupling the primary hydroxy group of this phenolic compound with several terminal diols of different chain lengths, by the use of a carbonate linker. The try...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2018-09, Vol.81 (9), p.2075-2082
Hauptverfasser:	Fernandez-Pastor, Ignacio, Martínez-García, Marta, Medina-O’Donnell, Marta, Rivas, Francisco, Martinez, Antonio, Pérez-Victoria, José María, Parra, Andres
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Humans Magnetic Resonance Spectroscopy Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - chemical synthesis Phenylethyl Alcohol - chemistry Phenylethyl Alcohol - pharmacology Structure-Activity Relationship Trypanocidal Agents - chemical synthesis Trypanosoma brucei brucei - drug effects
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