Role of Calcineurin in Stress Resistance, Morphogenesis, and Virulence of a Candida albicans Wild-Type Strain
By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamento...
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| Veröffentlicht in: | Infection and Immunity 2006-07, Vol.74 (7), p.4366-4369 |
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| container_title | Infection and Immunity |
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| creator | Bader, Teresa Schröppel, Klaus Bentink, Stefan Agabian, Nina Köhler, Gerwald Morschhäuser, Joachim |
| description | By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamentous growth in response to hypha-inducing environmental signals. While calcineurin was essential for virulence of C. albicans in a mouse model of disseminated candidiasis, deletion of CMP1 did not significantly affect virulence during vaginal or pulmonary infection, demonstrating that the requirement for calcineurin for a successful infection depends on the host niche. |
| doi_str_mv | 10.1128/IAI.00142-06 |
| format | Article |
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| source | American Society for Microbiology; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Biological and medical sciences Calcineurin - genetics Calcineurin - physiology Candida albicans Candida albicans - genetics Candida albicans - growth & development Candida albicans - pathogenicity Candida albicans - physiology Candidiasis - immunology Candidiasis - microbiology Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Fungal and Parasitic Infections Gene Silencing Immunity, Innate - genetics Mice Microbiology Miscellaneous Mycology Oxidative Stress - genetics Oxidative Stress - physiology Virulence - genetics |
| title | Role of Calcineurin in Stress Resistance, Morphogenesis, and Virulence of a Candida albicans Wild-Type Strain |
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