Enantioselective Intramolecular Nicholas Reaction Catalyzed by Chiral Phosphoric Acid: Enantioconvergent Synthesis of Seven‐Membered Cyclic Ethers from Racemic Diols

An enantioconvergent intramolecular Nicholas reaction of racemic diols was developed using BINOL‐ and SPINOL‐derived phosphoric acids as the chiral Brønsted acid catalyst. The developed reaction features an efficient approach to the synthesis of seven‐membered cyclic ethers in a highly enantioselect...

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Veröffentlicht in:	Angewandte Chemie International Edition 2018-10, Vol.57 (42), p.13917-13921
Hauptverfasser:	Ota, Yusuke, Kondoh, Azusa, Terada, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric catalysis Brønsted acids Chemical synthesis cyclizations Diols Enantiomers Ethers organocatalysis Phosphoric acid
Online-Zugang:	Volltext
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