Application of a direct pulp capping cement containing S-PRG filler
Objectives To evaluate new pulp capping cements containing surface pre-reacted glass ionomer (S-PRG) filler and to investigate ion release kinetics and pH shift of eluates from the cement. Materials and methods Molars of Wistar rats were directly pulp capped using three kinds of cement containing S-...
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| Veröffentlicht in: | Clinical oral investigations 2019-04, Vol.23 (4), p.1723-1731 |
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| creator | Takahashi, Yusuke Okamoto, Motoki Komichi, Shungo Imazato, Satoshi Nakatsuka, Toshiyuki Sakamoto, Shuji Kimoto, Katsuya Hayashi, Mikako |
| description | Objectives
To evaluate new pulp capping cements containing surface pre-reacted glass ionomer (S-PRG) filler and to investigate ion release kinetics and pH shift of eluates from the cement.
Materials and methods
Molars of Wistar rats were directly pulp capped using three kinds of cement containing S-PRG filler and mineral tri-oxide aggregate (MTA) was used as a control. After 1, 2, or 4 weeks, histological evaluation was performed and differences of tertiary dentin formation were analyzed. Release of Sr
2+
, BO
3
3−
, SiO
3
2−
, Na
+
, and Al
3+
ions was determined by inductively coupled plasma-atomic emission spectrometry, and F
−
ion release was measured using a fluoride ion selective electrode. The pH of the eluate from each cement after mixing was measured with a pH electrode.
Results
One of S-PRG cements promoted tertiary dentin formation to the same extent as the control (
p
> 0.05) and it showed a tendency of less inflammatory response. This cement released more BO
3
3−
and SiO
3
2−
, but less Sr
2+
, Na
+
, and F
−
than other S-PRG specimens. Each cement recovered nearly neutral compared with glass ionomer cement.
Conclusions
S-PRG cement induced tertiary dentin formation based on multiple ion releases, suggesting that it is suitable as a pulp capping material.
Clinical relevance
This new material can be an alternative pulp capping agent to MTA. |
| doi_str_mv | 10.1007/s00784-018-2596-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2097591321</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2096233866</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-166772bb35a51ff6193f086fb03c28add88f9e26f44e8d827c234dd974b6e603</originalsourceid><addsrcrecordid>eNp1kMtKxDAUhoMozjj6AG6k4MZNNJc2SZfDoKMwoOjsQ5omQ4ZeYtIufHtbOyoIbnJCznf-Ez4ALjG6xQjxuzgcIoUIC0iynEF2BOY4pQxSzvHx151Algs8A2cx7hHCKeP0FMwowlkuUDYHq6X3ldOqc22TtDZRSemC0V3i-8onWnnvml2iTW2aLtFt0ynXjC9v8OV1nVhXVSacgxOrqmguDnUBtg_329Uj3Dyvn1bLDdSUkw5ixjgnRUEzlWFrGc6pRYLZAlFNhCpLIWxuCLNpakQpCNeEpmWZ87RghiG6ADdTrA_te29iJ2sXtakq1Zi2j5KgnGc5pgQP6PUfdN_2oRk-N1KMUCoYGyg8UTq0MQZjpQ-uVuFDYiRHwXISLAfBchQsx5mrQ3Jf1Kb8mfg2OgBkAuLQanYm_K7-P_UTxpWDqQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2096233866</pqid></control><display><type>article</type><title>Application of a direct pulp capping cement containing S-PRG filler</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Takahashi, Yusuke ; Okamoto, Motoki ; Komichi, Shungo ; Imazato, Satoshi ; Nakatsuka, Toshiyuki ; Sakamoto, Shuji ; Kimoto, Katsuya ; Hayashi, Mikako</creator><creatorcontrib>Takahashi, Yusuke ; Okamoto, Motoki ; Komichi, Shungo ; Imazato, Satoshi ; Nakatsuka, Toshiyuki ; Sakamoto, Shuji ; Kimoto, Katsuya ; Hayashi, Mikako</creatorcontrib><description>Objectives
To evaluate new pulp capping cements containing surface pre-reacted glass ionomer (S-PRG) filler and to investigate ion release kinetics and pH shift of eluates from the cement.
Materials and methods
Molars of Wistar rats were directly pulp capped using three kinds of cement containing S-PRG filler and mineral tri-oxide aggregate (MTA) was used as a control. After 1, 2, or 4 weeks, histological evaluation was performed and differences of tertiary dentin formation were analyzed. Release of Sr
2+
, BO
3
3−
, SiO
3
2−
, Na
+
, and Al
3+
ions was determined by inductively coupled plasma-atomic emission spectrometry, and F
−
ion release was measured using a fluoride ion selective electrode. The pH of the eluate from each cement after mixing was measured with a pH electrode.
Results
One of S-PRG cements promoted tertiary dentin formation to the same extent as the control (
p
> 0.05) and it showed a tendency of less inflammatory response. This cement released more BO
3
3−
and SiO
3
2−
, but less Sr
2+
, Na
+
, and F
−
than other S-PRG specimens. Each cement recovered nearly neutral compared with glass ionomer cement.
Conclusions
S-PRG cement induced tertiary dentin formation based on multiple ion releases, suggesting that it is suitable as a pulp capping material.
Clinical relevance
This new material can be an alternative pulp capping agent to MTA.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-018-2596-6</identifier><identifier>PMID: 30159805</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acrylic Resins ; Aluminum ; Aluminum Compounds ; Animals ; Calcium Compounds ; Cement ; Dental cement ; Dental Pulp Capping ; Dentin ; Dentistry ; Drug Combinations ; Electrodes ; Glass Ionomer Cements ; Inflammation ; Medicine ; Molar ; Molars ; Original Article ; Oxides ; pH effects ; Pulp Capping and Pulpectomy Agents ; Rats ; Rats, Wistar ; Rodents ; Silicates ; Silicon Dioxide ; Teeth</subject><ispartof>Clinical oral investigations, 2019-04, Vol.23 (4), p.1723-1731</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Clinical Oral Investigations is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-166772bb35a51ff6193f086fb03c28add88f9e26f44e8d827c234dd974b6e603</citedby><cites>FETCH-LOGICAL-c372t-166772bb35a51ff6193f086fb03c28add88f9e26f44e8d827c234dd974b6e603</cites><orcidid>0000-0002-7974-1252</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-018-2596-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-018-2596-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30159805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi, Yusuke</creatorcontrib><creatorcontrib>Okamoto, Motoki</creatorcontrib><creatorcontrib>Komichi, Shungo</creatorcontrib><creatorcontrib>Imazato, Satoshi</creatorcontrib><creatorcontrib>Nakatsuka, Toshiyuki</creatorcontrib><creatorcontrib>Sakamoto, Shuji</creatorcontrib><creatorcontrib>Kimoto, Katsuya</creatorcontrib><creatorcontrib>Hayashi, Mikako</creatorcontrib><title>Application of a direct pulp capping cement containing S-PRG filler</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
To evaluate new pulp capping cements containing surface pre-reacted glass ionomer (S-PRG) filler and to investigate ion release kinetics and pH shift of eluates from the cement.
Materials and methods
Molars of Wistar rats were directly pulp capped using three kinds of cement containing S-PRG filler and mineral tri-oxide aggregate (MTA) was used as a control. After 1, 2, or 4 weeks, histological evaluation was performed and differences of tertiary dentin formation were analyzed. Release of Sr
2+
, BO
3
3−
, SiO
3
2−
, Na
+
, and Al
3+
ions was determined by inductively coupled plasma-atomic emission spectrometry, and F
−
ion release was measured using a fluoride ion selective electrode. The pH of the eluate from each cement after mixing was measured with a pH electrode.
Results
One of S-PRG cements promoted tertiary dentin formation to the same extent as the control (
p
> 0.05) and it showed a tendency of less inflammatory response. This cement released more BO
3
3−
and SiO
3
2−
, but less Sr
2+
, Na
+
, and F
−
than other S-PRG specimens. Each cement recovered nearly neutral compared with glass ionomer cement.
Conclusions
S-PRG cement induced tertiary dentin formation based on multiple ion releases, suggesting that it is suitable as a pulp capping material.
Clinical relevance
This new material can be an alternative pulp capping agent to MTA.</description><subject>Acrylic Resins</subject><subject>Aluminum</subject><subject>Aluminum Compounds</subject><subject>Animals</subject><subject>Calcium Compounds</subject><subject>Cement</subject><subject>Dental cement</subject><subject>Dental Pulp Capping</subject><subject>Dentin</subject><subject>Dentistry</subject><subject>Drug Combinations</subject><subject>Electrodes</subject><subject>Glass Ionomer Cements</subject><subject>Inflammation</subject><subject>Medicine</subject><subject>Molar</subject><subject>Molars</subject><subject>Original Article</subject><subject>Oxides</subject><subject>pH effects</subject><subject>Pulp Capping and Pulpectomy Agents</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Silicates</subject><subject>Silicon Dioxide</subject><subject>Teeth</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMtKxDAUhoMozjj6AG6k4MZNNJc2SZfDoKMwoOjsQ5omQ4ZeYtIufHtbOyoIbnJCznf-Ez4ALjG6xQjxuzgcIoUIC0iynEF2BOY4pQxSzvHx151Algs8A2cx7hHCKeP0FMwowlkuUDYHq6X3ldOqc22TtDZRSemC0V3i-8onWnnvml2iTW2aLtFt0ynXjC9v8OV1nVhXVSacgxOrqmguDnUBtg_329Uj3Dyvn1bLDdSUkw5ixjgnRUEzlWFrGc6pRYLZAlFNhCpLIWxuCLNpakQpCNeEpmWZ87RghiG6ADdTrA_te29iJ2sXtakq1Zi2j5KgnGc5pgQP6PUfdN_2oRk-N1KMUCoYGyg8UTq0MQZjpQ-uVuFDYiRHwXISLAfBchQsx5mrQ3Jf1Kb8mfg2OgBkAuLQanYm_K7-P_UTxpWDqQ</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Takahashi, Yusuke</creator><creator>Okamoto, Motoki</creator><creator>Komichi, Shungo</creator><creator>Imazato, Satoshi</creator><creator>Nakatsuka, Toshiyuki</creator><creator>Sakamoto, Shuji</creator><creator>Kimoto, Katsuya</creator><creator>Hayashi, Mikako</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7974-1252</orcidid></search><sort><creationdate>20190401</creationdate><title>Application of a direct pulp capping cement containing S-PRG filler</title><author>Takahashi, Yusuke ; Okamoto, Motoki ; Komichi, Shungo ; Imazato, Satoshi ; Nakatsuka, Toshiyuki ; Sakamoto, Shuji ; Kimoto, Katsuya ; Hayashi, Mikako</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-166772bb35a51ff6193f086fb03c28add88f9e26f44e8d827c234dd974b6e603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acrylic Resins</topic><topic>Aluminum</topic><topic>Aluminum Compounds</topic><topic>Animals</topic><topic>Calcium Compounds</topic><topic>Cement</topic><topic>Dental cement</topic><topic>Dental Pulp Capping</topic><topic>Dentin</topic><topic>Dentistry</topic><topic>Drug Combinations</topic><topic>Electrodes</topic><topic>Glass Ionomer Cements</topic><topic>Inflammation</topic><topic>Medicine</topic><topic>Molar</topic><topic>Molars</topic><topic>Original Article</topic><topic>Oxides</topic><topic>pH effects</topic><topic>Pulp Capping and Pulpectomy Agents</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Silicates</topic><topic>Silicon Dioxide</topic><topic>Teeth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Yusuke</creatorcontrib><creatorcontrib>Okamoto, Motoki</creatorcontrib><creatorcontrib>Komichi, Shungo</creatorcontrib><creatorcontrib>Imazato, Satoshi</creatorcontrib><creatorcontrib>Nakatsuka, Toshiyuki</creatorcontrib><creatorcontrib>Sakamoto, Shuji</creatorcontrib><creatorcontrib>Kimoto, Katsuya</creatorcontrib><creatorcontrib>Hayashi, Mikako</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Yusuke</au><au>Okamoto, Motoki</au><au>Komichi, Shungo</au><au>Imazato, Satoshi</au><au>Nakatsuka, Toshiyuki</au><au>Sakamoto, Shuji</au><au>Kimoto, Katsuya</au><au>Hayashi, Mikako</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of a direct pulp capping cement containing S-PRG filler</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>23</volume><issue>4</issue><spage>1723</spage><epage>1731</epage><pages>1723-1731</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
To evaluate new pulp capping cements containing surface pre-reacted glass ionomer (S-PRG) filler and to investigate ion release kinetics and pH shift of eluates from the cement.
Materials and methods
Molars of Wistar rats were directly pulp capped using three kinds of cement containing S-PRG filler and mineral tri-oxide aggregate (MTA) was used as a control. After 1, 2, or 4 weeks, histological evaluation was performed and differences of tertiary dentin formation were analyzed. Release of Sr
2+
, BO
3
3−
, SiO
3
2−
, Na
+
, and Al
3+
ions was determined by inductively coupled plasma-atomic emission spectrometry, and F
−
ion release was measured using a fluoride ion selective electrode. The pH of the eluate from each cement after mixing was measured with a pH electrode.
Results
One of S-PRG cements promoted tertiary dentin formation to the same extent as the control (
p
> 0.05) and it showed a tendency of less inflammatory response. This cement released more BO
3
3−
and SiO
3
2−
, but less Sr
2+
, Na
+
, and F
−
than other S-PRG specimens. Each cement recovered nearly neutral compared with glass ionomer cement.
Conclusions
S-PRG cement induced tertiary dentin formation based on multiple ion releases, suggesting that it is suitable as a pulp capping material.
Clinical relevance
This new material can be an alternative pulp capping agent to MTA.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30159805</pmid><doi>10.1007/s00784-018-2596-6</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7974-1252</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-6981 |
| ispartof | Clinical oral investigations, 2019-04, Vol.23 (4), p.1723-1731 |
| issn | 1432-6981 1436-3771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2097591321 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Acrylic Resins Aluminum Aluminum Compounds Animals Calcium Compounds Cement Dental cement Dental Pulp Capping Dentin Dentistry Drug Combinations Electrodes Glass Ionomer Cements Inflammation Medicine Molar Molars Original Article Oxides pH effects Pulp Capping and Pulpectomy Agents Rats Rats, Wistar Rodents Silicates Silicon Dioxide Teeth |
| title | Application of a direct pulp capping cement containing S-PRG filler |
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