Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila

Dendrite pruning of Drosophila sensory neurons during metamorphosis is induced by the steroid hormone ecdysone through a transcriptional program. In addition, ecdysone activates the eukaryotic initiation factor 4E-binding protein (4E-BP) to inhibit cap-dependent translation initiation. To uncover ho...

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Veröffentlicht in:	Cell reports (Cambridge) 2018-08, Vol.24 (9), p.2287-2299.e4
Hauptverfasser:	Rode, Sandra, Ohm, Henrike, Anhäuser, Lea, Wagner, Marina, Rosing, Mechthild, Deng, Xiaobing, Sin, Olga, Leidel, Sebastian A., Storkebaum, Erik, Rentmeister, Andrea, Zhu, Sijun, Rumpf, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	4E-BP 5′ UTR Animals Cell Differentiation dendrite Drosophila - metabolism Drosophila Proteins - metabolism ecdysone Ecdysone - genetics eIF3 eIF4A Eukaryotic Initiation Factor-4E - genetics Mical pruning
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