Fluorescent tracer in pilocarpine-treated rats shows widespread aberrant hippocampal neuronal connectivity

Neuronal fibres of the hippocampal formation of normal and chronic epileptic rats were investigated by fluorescent tracing methods using the pilocarpine model of limbic epilepsy. Two months after onset of spontaneous limbic seizures, hippocampal slices were prepared and maintained in vitro for 10 h....

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Veröffentlicht in:	The European journal of neuroscience 2001-07, Vol.14 (1), p.83-95
Hauptverfasser:	Lehmann, T.-N., Gabriel, S., Eilers, A., Njunting, M., Kovacs, R., Schulze, K., Lanksch, W. R., Heinemann, U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals area CA1 Axons - drug effects Axons - metabolism Axons - pathology Dendrites - drug effects Dendrites - metabolism Dendrites - pathology Dentate Gyrus - drug effects Dentate Gyrus - pathology Dentate Gyrus - physiopathology Disease Models, Animal Electric Stimulation epilepsy Epilepsy, Temporal Lobe - chemically induced Epilepsy, Temporal Lobe - pathology Epilepsy, Temporal Lobe - physiopathology fluorescent dextran-amine Fluorescent Dyes Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiopathology Male Muscarinic Agonists - pharmacology Neural Pathways - drug effects Neural Pathways - pathology Neural Pathways - physiopathology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology neuronal reorganization Pilocarpine - pharmacology pilocarpine model Pyramidal Cells - drug effects Pyramidal Cells - metabolism Pyramidal Cells - pathology Rats Rats, Wistar Seizures - chemically induced Seizures - pathology Seizures - physiopathology
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