VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones
In view of the neurotrophic effect of vasoactive intestinal peptide (VIP), the regulation of brain‐derived neurotrophic factor (BDNF) expression by VIP and the related peptide pituitary adenylate cyclase‐activating polypeptide (PACAP) was analysed by Northern blot in primary cultures of cortical neu...
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| Veröffentlicht in: | The European journal of neuroscience 1998-01, Vol.10 (1), p.272-280 |
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| creator | Pellegri, Giovanni Magistretti, Pierre J. Martin, Jean-Luc |
| description | In view of the neurotrophic effect of vasoactive intestinal peptide (VIP), the regulation of brain‐derived neurotrophic factor (BDNF) expression by VIP and the related peptide pituitary adenylate cyclase‐activating polypeptide (PACAP) was analysed by Northern blot in primary cultures of cortical neurones. Results reported in this article demonstrate that VIP and PACAP stimulate the expression of BDNF mRNA in primary cultures of cortical neurones and astrocytes. In primary cultures of cortical neurones, induction of BDNF mRNA by VIP and PACAP is completely inhibited by the N‐methyl‐d‐aspartate (NMDA) receptor antagonists MK‐801 and AP5, therefore indicating that VIP and PACAP do not stimulate BDNF expression directly but rather by potentiating the effect of glutamate tonically released by neurones and acting at NMDA receptors.
In addition to its neurotrophic effects, BDNF has been shown to be involved in neuronal plasticity and results reported here suggest that by stimulating BDNF expression, VIP and PACAP could modulate synaptic plasticity in the cerebral cortex. |
| doi_str_mv | 10.1046/j.1460-9568.1998.00052.x |
| format | Article |
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In addition to its neurotrophic effects, BDNF has been shown to be involved in neuronal plasticity and results reported here suggest that by stimulating BDNF expression, VIP and PACAP could modulate synaptic plasticity in the cerebral cortex.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1046/j.1460-9568.1998.00052.x</identifier><identifier>PMID: 9753136</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science, Ltd</publisher><subject>2-Amino-5-phosphonovalerate - pharmacology ; 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology ; Alanine - analogs & derivatives ; Alanine - pharmacology ; Animals ; Astrocytes - cytology ; Blotting, Northern ; Brain-Derived Neurotrophic Factor - genetics ; Cells, Cultured ; cerebral cortex ; Cerebral Cortex - cytology ; Dizocilpine Maleate - pharmacology ; Drug Synergism ; Excitatory Amino Acid Antagonists - pharmacology ; Gene Expression - drug effects ; Glutamic Acid - pharmacology ; Mice ; mouse ; Neuromodulation ; Neuronal Plasticity - drug effects ; Neuronal Plasticity - physiology ; Neurons - chemistry ; Neurons - cytology ; Neurons - drug effects ; neuropeptide ; Neuropeptides - pharmacology ; Neurotransmitter Agents - pharmacology ; neurotrophin ; Pituitary Adenylate Cyclase-Activating Polypeptide ; Receptors, N-Methyl-D-Aspartate - physiology ; RNA, Messenger - analysis ; Vasoactive Intestinal Peptide - pharmacology</subject><ispartof>The European journal of neuroscience, 1998-01, Vol.10 (1), p.272-280</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4982-9f20dab9d3479b53ddc0773d7ea0b82b7798442fa92107ee5f4f35613b964a683</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1460-9568.1998.00052.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1460-9568.1998.00052.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9753136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pellegri, Giovanni</creatorcontrib><creatorcontrib>Magistretti, Pierre J.</creatorcontrib><creatorcontrib>Martin, Jean-Luc</creatorcontrib><title>VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>In view of the neurotrophic effect of vasoactive intestinal peptide (VIP), the regulation of brain‐derived neurotrophic factor (BDNF) expression by VIP and the related peptide pituitary adenylate cyclase‐activating polypeptide (PACAP) was analysed by Northern blot in primary cultures of cortical neurones. Results reported in this article demonstrate that VIP and PACAP stimulate the expression of BDNF mRNA in primary cultures of cortical neurones and astrocytes. In primary cultures of cortical neurones, induction of BDNF mRNA by VIP and PACAP is completely inhibited by the N‐methyl‐d‐aspartate (NMDA) receptor antagonists MK‐801 and AP5, therefore indicating that VIP and PACAP do not stimulate BDNF expression directly but rather by potentiating the effect of glutamate tonically released by neurones and acting at NMDA receptors.
In addition to its neurotrophic effects, BDNF has been shown to be involved in neuronal plasticity and results reported here suggest that by stimulating BDNF expression, VIP and PACAP could modulate synaptic plasticity in the cerebral cortex.</description><subject>2-Amino-5-phosphonovalerate - pharmacology</subject><subject>6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology</subject><subject>Alanine - analogs & derivatives</subject><subject>Alanine - pharmacology</subject><subject>Animals</subject><subject>Astrocytes - cytology</subject><subject>Blotting, Northern</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Cells, Cultured</subject><subject>cerebral cortex</subject><subject>Cerebral Cortex - cytology</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Drug Synergism</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Gene Expression - drug effects</subject><subject>Glutamic Acid - pharmacology</subject><subject>Mice</subject><subject>mouse</subject><subject>Neuromodulation</subject><subject>Neuronal Plasticity - drug effects</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neurons - chemistry</subject><subject>Neurons - cytology</subject><subject>Neurons - drug effects</subject><subject>neuropeptide</subject><subject>Neuropeptides - pharmacology</subject><subject>Neurotransmitter Agents - pharmacology</subject><subject>neurotrophin</subject><subject>Pituitary Adenylate Cyclase-Activating Polypeptide</subject><subject>Receptors, N-Methyl-D-Aspartate - physiology</subject><subject>RNA, Messenger - analysis</subject><subject>Vasoactive Intestinal Peptide - pharmacology</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkFtv0zAYhi0EGmXwE5B8xV2CHZ8lbkq3dZtG14ux7QrLSb5ASg6d7Yju35OsVa935cP7Pp-tByFMSUoJl183KeWSJEZInVJjdEoIEVm6e4Nmx-AtmhEjWKKpfHyPPoSwGUtacnGCTowSjDI5Q7_ur9bYdSVezxfzNd72EbpYuwg4_gHsilj3He4r_LsZomun-_H8_Wx1gWG39RDClNcdbvshAC56H-vCNbiDwfcdhI_oXeWaAJ8O6yn6eXF-t7hMbm6XV4v5TVJwo7PEVBkpXW5KxpXJBSvLgijFSgWO5DrLlTKa86xyJqNEAYiKV0xIynIjuZOanaIv-7lb3z8NEKJt61BA07gOxp_ZjBhFpJBjUe-Lhe9D8FDZra9b558tJXZSazd2Mmgng3ZSa1_U2t2Ifj68MeQtlEfw4HLMv-3zf3UDz6-ea8-vV-NmxJM9XocIuyPu_F8rFVPCPqyW9vLO_DijS2If2X_yS5XO</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Pellegri, Giovanni</creator><creator>Magistretti, Pierre J.</creator><creator>Martin, Jean-Luc</creator><general>Blackwell Science, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>199801</creationdate><title>VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones</title><author>Pellegri, Giovanni ; Magistretti, Pierre J. ; Martin, Jean-Luc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4982-9f20dab9d3479b53ddc0773d7ea0b82b7798442fa92107ee5f4f35613b964a683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>2-Amino-5-phosphonovalerate - pharmacology</topic><topic>6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology</topic><topic>Alanine - analogs & derivatives</topic><topic>Alanine - pharmacology</topic><topic>Animals</topic><topic>Astrocytes - cytology</topic><topic>Blotting, Northern</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Cells, Cultured</topic><topic>cerebral cortex</topic><topic>Cerebral Cortex - cytology</topic><topic>Dizocilpine Maleate - pharmacology</topic><topic>Drug Synergism</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Gene Expression - drug effects</topic><topic>Glutamic Acid - pharmacology</topic><topic>Mice</topic><topic>mouse</topic><topic>Neuromodulation</topic><topic>Neuronal Plasticity - drug effects</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neurons - chemistry</topic><topic>Neurons - cytology</topic><topic>Neurons - drug effects</topic><topic>neuropeptide</topic><topic>Neuropeptides - pharmacology</topic><topic>Neurotransmitter Agents - pharmacology</topic><topic>neurotrophin</topic><topic>Pituitary Adenylate Cyclase-Activating Polypeptide</topic><topic>Receptors, N-Methyl-D-Aspartate - physiology</topic><topic>RNA, Messenger - analysis</topic><topic>Vasoactive Intestinal Peptide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pellegri, Giovanni</creatorcontrib><creatorcontrib>Magistretti, Pierre J.</creatorcontrib><creatorcontrib>Martin, Jean-Luc</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pellegri, Giovanni</au><au>Magistretti, Pierre J.</au><au>Martin, Jean-Luc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>1998-01</date><risdate>1998</risdate><volume>10</volume><issue>1</issue><spage>272</spage><epage>280</epage><pages>272-280</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>In view of the neurotrophic effect of vasoactive intestinal peptide (VIP), the regulation of brain‐derived neurotrophic factor (BDNF) expression by VIP and the related peptide pituitary adenylate cyclase‐activating polypeptide (PACAP) was analysed by Northern blot in primary cultures of cortical neurones. Results reported in this article demonstrate that VIP and PACAP stimulate the expression of BDNF mRNA in primary cultures of cortical neurones and astrocytes. In primary cultures of cortical neurones, induction of BDNF mRNA by VIP and PACAP is completely inhibited by the N‐methyl‐d‐aspartate (NMDA) receptor antagonists MK‐801 and AP5, therefore indicating that VIP and PACAP do not stimulate BDNF expression directly but rather by potentiating the effect of glutamate tonically released by neurones and acting at NMDA receptors.
In addition to its neurotrophic effects, BDNF has been shown to be involved in neuronal plasticity and results reported here suggest that by stimulating BDNF expression, VIP and PACAP could modulate synaptic plasticity in the cerebral cortex.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science, Ltd</pub><pmid>9753136</pmid><doi>10.1046/j.1460-9568.1998.00052.x</doi><tpages>9</tpages></addata></record> |
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| subjects | 2-Amino-5-phosphonovalerate - pharmacology 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Alanine - analogs & derivatives Alanine - pharmacology Animals Astrocytes - cytology Blotting, Northern Brain-Derived Neurotrophic Factor - genetics Cells, Cultured cerebral cortex Cerebral Cortex - cytology Dizocilpine Maleate - pharmacology Drug Synergism Excitatory Amino Acid Antagonists - pharmacology Gene Expression - drug effects Glutamic Acid - pharmacology Mice mouse Neuromodulation Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurons - chemistry Neurons - cytology Neurons - drug effects neuropeptide Neuropeptides - pharmacology Neurotransmitter Agents - pharmacology neurotrophin Pituitary Adenylate Cyclase-Activating Polypeptide Receptors, N-Methyl-D-Aspartate - physiology RNA, Messenger - analysis Vasoactive Intestinal Peptide - pharmacology |
| title | VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones |
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