Simultaneous Expression of Long-term Depression of NMDA and Long-term Potentiation of AMPA Receptor-mediated Synaptic Responses in the CA1 Area of the Kainic Acid-lesioned Hippocampus

This study investigates the plasticity of the excitatory synapses in an experimental model of epilepsy, the kainic acid‐lesioned rat hippocampus. Stimulation of afferents in the CA1 area of lesioned hippocampi produced an epileptiform burst of action potentials, with an underlying synaptic potential...

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Veröffentlicht in:	The European journal of neuroscience 1995-07, Vol.7 (7), p.1651-1655
Hauptverfasser:	Bernard, Christophe L., Wheal, Howard V.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - pharmacology 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Action Potentials Animals Electric Stimulation Epilepsy, Temporal Lobe - chemically induced Epilepsy, Temporal Lobe - physiopathology Excitatory Amino Acid Antagonists - pharmacology Hippocampus - drug effects Hippocampus - physiopathology Kainic Acid learning Long-Term Potentiation Male memory Rats Rats, Wistar Receptors, AMPA - physiology Receptors, N-Methyl-D-Aspartate - physiology Synapses - physiology synaptic plasticity Synaptic Transmission - drug effects temporal lobe epilepsy
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