Reduced alpha 4 beta 1 Integrin-VCAM-1 Interactions Lead to Impaired Pre-B Cell Repopulation in Alpha 1,6-Fucosyltransferase Deficient Mice

Mice with a targeted gene disruption of Fut8 (Fut8--- ) showed an abnormality in the transition from pro-B cell to pre-B cell, reduced peripheral B cells, and a decreased immunoglobulin production. Alpha 1,6-fucosyltransferase (FUT8) is responsible for the alpha 1,6 core fucosylation of N-glycans, w...

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Veröffentlicht in:	Glycobiology (Oxford) 2008-01, Vol.18 (1), p.114-124
Hauptverfasser:	Li, Wenzhe, Ishihara, Katsuhiko, Yokota, Takafumi, Nakagawa, Takatoshi, Koyama, Nobuto, Jin, Jinhua, Mizuno-Horikawa, Yoko, Wang, Xiangchun, Miyoshi, Eiji, Taniguchi, Naoyuki, Kondo, Akihiro
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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