Reprogramming of human somatic cells to pluripotency with defined factors

Pluripotency pertains to the cells of early embryos that can generate all of the tissues in the organism. Embryonic stem cells are embryo-derived cell lines that retain pluripotency and represent invaluable tools for research into the mechanisms of tissue formation. Recently, murine fibroblasts have...

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Veröffentlicht in:	Nature 2008-01, Vol.451 (7175), p.141-146
Hauptverfasser:	Daley, George Q, Park, In-Hyun, Zhao, Rui, West, Jason A, Yabuuchi, Akiko, Huo, Hongguang, Ince, Tan A, Lerou, Paul H, Lensch, M. William
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biological and medical sciences Biomedical research Cell culture Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell Shape Cells, Cultured Cellular biology DNA binding proteins DNA Methylation DNA-Binding Proteins - genetics Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Embryos Fetus - cytology Fibroblasts - cytology Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Genetic aspects Genetic engineering HMGB Proteins - genetics HMGB Proteins - metabolism Homeodomain Proteins - genetics Humanities and Social Sciences Humans Infant, Newborn Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Mice Molecular and cellular biology multidisciplinary Nanog Homeobox Protein Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Physiological aspects Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Pluripotent Stem Cells - transplantation Promoter Regions, Genetic - genetics Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Science Science (multidisciplinary) Somatic cells SOXB1 Transcription Factors Stem cells Teratoma - pathology Transcription Factors - genetics Transcription Factors - metabolism Transplantation, Heterologous
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