Strong correlation between the concentration of dioxins and total PCBs in current Japanese people
The purpose of this study was to establish an economic and efficient method to screen total PCBs and total dioxins (PCDDs + PCDFs + Co-PCBs) in the highly exposed people in Japan. In this paper, we suggest use of total PCBs in human blood to represent other persistent organic pollutants, especially...
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| Veröffentlicht in: | Chemosphere (Oxford) 2008-08, Vol.73 (1), p.S235-S238 |
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| creator | Mori, Chisato Fukata, Hideki Sakurai, Kenichi Jotaki, Tomomi Todaka, Emiko Saito, Yasushi |
| description | The purpose of this study was to establish an economic and efficient method to screen total PCBs and total dioxins (PCDDs
+
PCDFs
+
Co-PCBs) in the highly exposed people in Japan. In this paper, we suggest use of total PCBs in human blood to represent other persistent organic pollutants, especially dioxins. Twenty blood samples were collected from Japanese volunteers. Total PCBs and total dioxins (PCDDs
+
PCDFs
+
Co-PCBs) were detected from all twenty blood samples. We carried out detailed analysis of correlation between concentration of total PCBs and each dioxin congener with both measured value and TEQ calculated value. The mean concentration of total PCBs was 250
ng
g-fat
−1, and the mean concentration of total dioxins was 37
ng
g-fat
−1 or 40
pg TEQ g-fat
−1. Correlations between the total PCBs (ng
g-fat
−1) and the total measured dioxins (ng
g-fat
−1), and between the total PCBs (ng
g-fat
−1) and the total dioxin TEQ calculated value (pg-TEQ
g-fat
−1) were 0.95 and 0.90, respectively. It became clear that the concentrations of total PCBs in human blood is a good indicator of the concentrations of total dioxins in Japan. If a mass screening is conducted on women of reproductive age in order to detect highly exposed women, it is possible that women with the highest contamination may be treated in order to decrease the levels of these chemicals before pregnancy. In conclusion, measurement of total PCBs concentration is useful for exposure assessment of dioxins in human blood. |
| doi_str_mv | 10.1016/j.chemosphere.2007.12.038 |
| format | Article |
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+
PCDFs
+
Co-PCBs) in the highly exposed people in Japan. In this paper, we suggest use of total PCBs in human blood to represent other persistent organic pollutants, especially dioxins. Twenty blood samples were collected from Japanese volunteers. Total PCBs and total dioxins (PCDDs
+
PCDFs
+
Co-PCBs) were detected from all twenty blood samples. We carried out detailed analysis of correlation between concentration of total PCBs and each dioxin congener with both measured value and TEQ calculated value. The mean concentration of total PCBs was 250
ng
g-fat
−1, and the mean concentration of total dioxins was 37
ng
g-fat
−1 or 40
pg TEQ g-fat
−1. Correlations between the total PCBs (ng
g-fat
−1) and the total measured dioxins (ng
g-fat
−1), and between the total PCBs (ng
g-fat
−1) and the total dioxin TEQ calculated value (pg-TEQ
g-fat
−1) were 0.95 and 0.90, respectively. It became clear that the concentrations of total PCBs in human blood is a good indicator of the concentrations of total dioxins in Japan. If a mass screening is conducted on women of reproductive age in order to detect highly exposed women, it is possible that women with the highest contamination may be treated in order to decrease the levels of these chemicals before pregnancy. In conclusion, measurement of total PCBs concentration is useful for exposure assessment of dioxins in human blood.</description><identifier>ISSN: 0045-6535</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2007.12.038</identifier><identifier>PMID: 18439647</identifier><identifier>CODEN: CMSHAF</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Asian Continental Ancestry Group ; Biological and medical sciences ; Dioxins - blood ; Environmental Monitoring - economics ; Environmental Monitoring - methods ; Environmental Monitoring - statistics & numerical data ; Environmental Pollutants - blood ; Environmental pollutants toxicology ; Female ; General aspects ; Human blood ; Humans ; Male ; Medical sciences ; Middle Aged ; Persistent chemicals ; Polychlorinated Biphenyls - blood ; Reproductive age group ; Screening ; Toxicology</subject><ispartof>Chemosphere (Oxford), 2008-08, Vol.73 (1), p.S235-S238</ispartof><rights>2008 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-88e21d2015e461c1c045fe30f7ad838fbcd7c5bbb3d06a38196bebee2dfe7e6b3</citedby><cites>FETCH-LOGICAL-c533t-88e21d2015e461c1c045fe30f7ad838fbcd7c5bbb3d06a38196bebee2dfe7e6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chemosphere.2007.12.038$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20738683$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18439647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mori, Chisato</creatorcontrib><creatorcontrib>Fukata, Hideki</creatorcontrib><creatorcontrib>Sakurai, Kenichi</creatorcontrib><creatorcontrib>Jotaki, Tomomi</creatorcontrib><creatorcontrib>Todaka, Emiko</creatorcontrib><creatorcontrib>Saito, Yasushi</creatorcontrib><title>Strong correlation between the concentration of dioxins and total PCBs in current Japanese people</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>The purpose of this study was to establish an economic and efficient method to screen total PCBs and total dioxins (PCDDs
+
PCDFs
+
Co-PCBs) in the highly exposed people in Japan. In this paper, we suggest use of total PCBs in human blood to represent other persistent organic pollutants, especially dioxins. Twenty blood samples were collected from Japanese volunteers. Total PCBs and total dioxins (PCDDs
+
PCDFs
+
Co-PCBs) were detected from all twenty blood samples. We carried out detailed analysis of correlation between concentration of total PCBs and each dioxin congener with both measured value and TEQ calculated value. The mean concentration of total PCBs was 250
ng
g-fat
−1, and the mean concentration of total dioxins was 37
ng
g-fat
−1 or 40
pg TEQ g-fat
−1. Correlations between the total PCBs (ng
g-fat
−1) and the total measured dioxins (ng
g-fat
−1), and between the total PCBs (ng
g-fat
−1) and the total dioxin TEQ calculated value (pg-TEQ
g-fat
−1) were 0.95 and 0.90, respectively. It became clear that the concentrations of total PCBs in human blood is a good indicator of the concentrations of total dioxins in Japan. If a mass screening is conducted on women of reproductive age in order to detect highly exposed women, it is possible that women with the highest contamination may be treated in order to decrease the levels of these chemicals before pregnancy. In conclusion, measurement of total PCBs concentration is useful for exposure assessment of dioxins in human blood.</description><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Dioxins - blood</subject><subject>Environmental Monitoring - economics</subject><subject>Environmental Monitoring - methods</subject><subject>Environmental Monitoring - statistics & numerical data</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental pollutants toxicology</subject><subject>Female</subject><subject>General aspects</subject><subject>Human blood</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Persistent chemicals</subject><subject>Polychlorinated Biphenyls - blood</subject><subject>Reproductive age group</subject><subject>Screening</subject><subject>Toxicology</subject><issn>0045-6535</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuPFCEURonROD2jf8HgQndV8qgCaqmd0dFMoom6Jjxu2XSqoQTax7-XSXfUna5I4HyXL_cg9JSSnhIqXux7t4NDKusOMvSMENlT1hOu7qENVXLqKJvUfbQhZBg7MfLxAl2WsiekhcfpIbqgauCTGOQGmY81p_gFu5QzLKaGFLGF-h0g4rqDdh8dxJpPL2nGPqQfIRZsosc1VbPgD9tXBYeI3bGNiBW_M6uJUACvkNYFHqEHs1kKPD6fV-jz6-tP25vu9v2bt9uXt50bOa-dUsCoZ4SOMAjqqGvdZ-BklsYrrmbrvHSjtZZ7IgxXdBIWLADzM0gQll-h56e5a05fj1CqPoTiYFlamXQsmpFpnOTA_gnSQQnGhWzgdAJdTqVkmPWaw8Hkn5oSfSdC7_VfIvSdCE2ZbiJa9sn5k6M9gP-TPG--Ac_OgCnOLHM20YXym2NEciUUb9z2xEHb3bcAWRcXoEnxIYOr2qfwH3V-AUNbrtQ</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Mori, Chisato</creator><creator>Fukata, Hideki</creator><creator>Sakurai, Kenichi</creator><creator>Jotaki, Tomomi</creator><creator>Todaka, Emiko</creator><creator>Saito, Yasushi</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TV</scope><scope>7U7</scope></search><sort><creationdate>20080801</creationdate><title>Strong correlation between the concentration of dioxins and total PCBs in current Japanese people</title><author>Mori, Chisato ; Fukata, Hideki ; Sakurai, Kenichi ; Jotaki, Tomomi ; Todaka, Emiko ; Saito, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-88e21d2015e461c1c045fe30f7ad838fbcd7c5bbb3d06a38196bebee2dfe7e6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Dioxins - blood</topic><topic>Environmental Monitoring - economics</topic><topic>Environmental Monitoring - methods</topic><topic>Environmental Monitoring - statistics & numerical data</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental pollutants toxicology</topic><topic>Female</topic><topic>General aspects</topic><topic>Human blood</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Persistent chemicals</topic><topic>Polychlorinated Biphenyls - blood</topic><topic>Reproductive age group</topic><topic>Screening</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mori, Chisato</creatorcontrib><creatorcontrib>Fukata, Hideki</creatorcontrib><creatorcontrib>Sakurai, Kenichi</creatorcontrib><creatorcontrib>Jotaki, Tomomi</creatorcontrib><creatorcontrib>Todaka, Emiko</creatorcontrib><creatorcontrib>Saito, Yasushi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mori, Chisato</au><au>Fukata, Hideki</au><au>Sakurai, Kenichi</au><au>Jotaki, Tomomi</au><au>Todaka, Emiko</au><au>Saito, Yasushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Strong correlation between the concentration of dioxins and total PCBs in current Japanese people</atitle><jtitle>Chemosphere (Oxford)</jtitle><addtitle>Chemosphere</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>73</volume><issue>1</issue><spage>S235</spage><epage>S238</epage><pages>S235-S238</pages><issn>0045-6535</issn><eissn>1879-1298</eissn><coden>CMSHAF</coden><abstract>The purpose of this study was to establish an economic and efficient method to screen total PCBs and total dioxins (PCDDs
+
PCDFs
+
Co-PCBs) in the highly exposed people in Japan. In this paper, we suggest use of total PCBs in human blood to represent other persistent organic pollutants, especially dioxins. Twenty blood samples were collected from Japanese volunteers. Total PCBs and total dioxins (PCDDs
+
PCDFs
+
Co-PCBs) were detected from all twenty blood samples. We carried out detailed analysis of correlation between concentration of total PCBs and each dioxin congener with both measured value and TEQ calculated value. The mean concentration of total PCBs was 250
ng
g-fat
−1, and the mean concentration of total dioxins was 37
ng
g-fat
−1 or 40
pg TEQ g-fat
−1. Correlations between the total PCBs (ng
g-fat
−1) and the total measured dioxins (ng
g-fat
−1), and between the total PCBs (ng
g-fat
−1) and the total dioxin TEQ calculated value (pg-TEQ
g-fat
−1) were 0.95 and 0.90, respectively. It became clear that the concentrations of total PCBs in human blood is a good indicator of the concentrations of total dioxins in Japan. If a mass screening is conducted on women of reproductive age in order to detect highly exposed women, it is possible that women with the highest contamination may be treated in order to decrease the levels of these chemicals before pregnancy. In conclusion, measurement of total PCBs concentration is useful for exposure assessment of dioxins in human blood.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>18439647</pmid><doi>10.1016/j.chemosphere.2007.12.038</doi></addata></record> |
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| issn | 0045-6535 1879-1298 |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Asian Continental Ancestry Group Biological and medical sciences Dioxins - blood Environmental Monitoring - economics Environmental Monitoring - methods Environmental Monitoring - statistics & numerical data Environmental Pollutants - blood Environmental pollutants toxicology Female General aspects Human blood Humans Male Medical sciences Middle Aged Persistent chemicals Polychlorinated Biphenyls - blood Reproductive age group Screening Toxicology |
| title | Strong correlation between the concentration of dioxins and total PCBs in current Japanese people |
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