Osteoblastoma‐like osteosarcoma: high‐grade or low‐grade osteosarcoma?
Aims Osteoblastoma‐like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current World Health Organisation (WHO) classification, osteoblastoma‐like osteosarcoma is classified within the group of conventional (high‐grade) osteos...
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| Veröffentlicht in: | Histopathology 2019-02, Vol.74 (3), p.494-503 |
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| creator | Gambarotti, Marco Dei Tos, Angelo P Vanel, Daniel Picci, Piero Gibertoni, Dino Klein, Michael J Righi, Alberto |
| description | Aims
Osteoblastoma‐like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current World Health Organisation (WHO) classification, osteoblastoma‐like osteosarcoma is classified within the group of conventional (high‐grade) osteosarcomas. However, several published cases have been actually regarded as low‐grade malignant tumours. As strict morphological criteria to distinguish between low‐ and high‐grade lesions are not available, we reviewed our series of osteoblastoma‐like osteosarcomas in the attempt to identify clinical and morphological features predictive of aggressiveness.
Methods and results
We retrieved 15 cases of osteoblastoma‐like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis and five patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while four patients died of their disease. Statistical analysis revealed a statistically significant (P = 0.048) lower disease‐free survival in patients with areas of conventional (high‐grade) osteosarcoma.
Conclusions
With the important limitation of a small cohort of patients, the presence of areas of conventional (high‐grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma‐like osteosarcoma. |
| doi_str_mv | 10.1111/his.13746 |
| format | Article |
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Osteoblastoma‐like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current World Health Organisation (WHO) classification, osteoblastoma‐like osteosarcoma is classified within the group of conventional (high‐grade) osteosarcomas. However, several published cases have been actually regarded as low‐grade malignant tumours. As strict morphological criteria to distinguish between low‐ and high‐grade lesions are not available, we reviewed our series of osteoblastoma‐like osteosarcomas in the attempt to identify clinical and morphological features predictive of aggressiveness.
Methods and results
We retrieved 15 cases of osteoblastoma‐like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis and five patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while four patients died of their disease. Statistical analysis revealed a statistically significant (P = 0.048) lower disease‐free survival in patients with areas of conventional (high‐grade) osteosarcoma.
Conclusions
With the important limitation of a small cohort of patients, the presence of areas of conventional (high‐grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma‐like osteosarcoma.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.13746</identifier><identifier>PMID: 30152881</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adult ; Bone cancer ; Bone Neoplasms - mortality ; Bone Neoplasms - pathology ; Child ; Disease-Free Survival ; Female ; grading ; Humans ; Kaplan-Meier Estimate ; Male ; Metastases ; Middle Aged ; Morphology ; Neoplasm Grading ; Osteoblastoma ; Osteoblastoma - mortality ; Osteoblastoma - pathology ; Osteosarcoma ; Osteosarcoma - mortality ; Osteosarcoma - pathology ; prognosis ; Statistical analysis ; Surgery ; Tumors ; Young Adult</subject><ispartof>Histopathology, 2019-02, Vol.74 (3), p.494-503</ispartof><rights>2018 John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4196-6b96d1f61e7c44ed1f1e4d9d37c3dcdc99b9cde468dca7c6a4fa53a917bc1333</citedby><cites>FETCH-LOGICAL-c4196-6b96d1f61e7c44ed1f1e4d9d37c3dcdc99b9cde468dca7c6a4fa53a917bc1333</cites><orcidid>0000-0002-1074-0155</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhis.13746$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhis.13746$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30152881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gambarotti, Marco</creatorcontrib><creatorcontrib>Dei Tos, Angelo P</creatorcontrib><creatorcontrib>Vanel, Daniel</creatorcontrib><creatorcontrib>Picci, Piero</creatorcontrib><creatorcontrib>Gibertoni, Dino</creatorcontrib><creatorcontrib>Klein, Michael J</creatorcontrib><creatorcontrib>Righi, Alberto</creatorcontrib><title>Osteoblastoma‐like osteosarcoma: high‐grade or low‐grade osteosarcoma?</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
Osteoblastoma‐like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current World Health Organisation (WHO) classification, osteoblastoma‐like osteosarcoma is classified within the group of conventional (high‐grade) osteosarcomas. However, several published cases have been actually regarded as low‐grade malignant tumours. As strict morphological criteria to distinguish between low‐ and high‐grade lesions are not available, we reviewed our series of osteoblastoma‐like osteosarcomas in the attempt to identify clinical and morphological features predictive of aggressiveness.
Methods and results
We retrieved 15 cases of osteoblastoma‐like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis and five patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while four patients died of their disease. Statistical analysis revealed a statistically significant (P = 0.048) lower disease‐free survival in patients with areas of conventional (high‐grade) osteosarcoma.
Conclusions
With the important limitation of a small cohort of patients, the presence of areas of conventional (high‐grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma‐like osteosarcoma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bone cancer</subject><subject>Bone Neoplasms - mortality</subject><subject>Bone Neoplasms - pathology</subject><subject>Child</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>grading</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Neoplasm Grading</subject><subject>Osteoblastoma</subject><subject>Osteoblastoma - mortality</subject><subject>Osteoblastoma - pathology</subject><subject>Osteosarcoma</subject><subject>Osteosarcoma - mortality</subject><subject>Osteosarcoma - pathology</subject><subject>prognosis</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUhoMotlYXvoAU3Ohi2mRymYkbkaK2UOjC7kMmybRTZ5qadCjd-Qg-o09i6tQLgocD5_bxc_gBOEewh0L054XvIZwQdgDaCDMaxZTyQ9CGGPIIIpa0wIn3CwhRguP4GLQwRDROU9QG44lfG5uV0q9tJd9f38ri2XTtbumlU2F3050Xs3m4zJzU4eS6pd38jL_I21NwlMvSm7N97YDpw_10MIzGk8fR4G4cKYI4i1jGmUY5QyZRhJjQIkM01zhRWCutOM-40oawVCuZKCZJLimWHCWZQhjjDrhqZFfOvtTGr0VVeGXKUi6Nrb2IIaeU0JTDgF7-QRe2dsvwnIgRY5zHIQN13VDKWe-dycXKFZV0W4Gg2DksgsPi0-HAXuwV66wy-pv8sjQA_QbYFKXZ_q8khqOnRvIDduOIlA</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Gambarotti, Marco</creator><creator>Dei Tos, Angelo P</creator><creator>Vanel, Daniel</creator><creator>Picci, Piero</creator><creator>Gibertoni, Dino</creator><creator>Klein, Michael J</creator><creator>Righi, Alberto</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1074-0155</orcidid></search><sort><creationdate>201902</creationdate><title>Osteoblastoma‐like osteosarcoma: high‐grade or low‐grade osteosarcoma?</title><author>Gambarotti, Marco ; Dei Tos, Angelo P ; Vanel, Daniel ; Picci, Piero ; Gibertoni, Dino ; Klein, Michael J ; Righi, Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4196-6b96d1f61e7c44ed1f1e4d9d37c3dcdc99b9cde468dca7c6a4fa53a917bc1333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Bone cancer</topic><topic>Bone Neoplasms - mortality</topic><topic>Bone Neoplasms - pathology</topic><topic>Child</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>grading</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Neoplasm Grading</topic><topic>Osteoblastoma</topic><topic>Osteoblastoma - mortality</topic><topic>Osteoblastoma - pathology</topic><topic>Osteosarcoma</topic><topic>Osteosarcoma - mortality</topic><topic>Osteosarcoma - pathology</topic><topic>prognosis</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gambarotti, Marco</creatorcontrib><creatorcontrib>Dei Tos, Angelo P</creatorcontrib><creatorcontrib>Vanel, Daniel</creatorcontrib><creatorcontrib>Picci, Piero</creatorcontrib><creatorcontrib>Gibertoni, Dino</creatorcontrib><creatorcontrib>Klein, Michael J</creatorcontrib><creatorcontrib>Righi, Alberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gambarotti, Marco</au><au>Dei Tos, Angelo P</au><au>Vanel, Daniel</au><au>Picci, Piero</au><au>Gibertoni, Dino</au><au>Klein, Michael J</au><au>Righi, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteoblastoma‐like osteosarcoma: high‐grade or low‐grade osteosarcoma?</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2019-02</date><risdate>2019</risdate><volume>74</volume><issue>3</issue><spage>494</spage><epage>503</epage><pages>494-503</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims
Osteoblastoma‐like osteosarcoma is a rare variant of osteosarcoma (1% of all osteosarcomas), histologically similar to osteoblastoma. In the current World Health Organisation (WHO) classification, osteoblastoma‐like osteosarcoma is classified within the group of conventional (high‐grade) osteosarcomas. However, several published cases have been actually regarded as low‐grade malignant tumours. As strict morphological criteria to distinguish between low‐ and high‐grade lesions are not available, we reviewed our series of osteoblastoma‐like osteosarcomas in the attempt to identify clinical and morphological features predictive of aggressiveness.
Methods and results
We retrieved 15 cases of osteoblastoma‐like osteosarcoma from the files of the Istituto Ortopedico Rizzoli. Patients received various treatments. Five patients developed metastasis and five patients developed local recurrences (all after incomplete surgery). Eleven patients were alive without disease, while four patients died of their disease. Statistical analysis revealed a statistically significant (P = 0.048) lower disease‐free survival in patients with areas of conventional (high‐grade) osteosarcoma.
Conclusions
With the important limitation of a small cohort of patients, the presence of areas of conventional (high‐grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma‐like osteosarcoma.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30152881</pmid><doi>10.1111/his.13746</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1074-0155</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Bone cancer Bone Neoplasms - mortality Bone Neoplasms - pathology Child Disease-Free Survival Female grading Humans Kaplan-Meier Estimate Male Metastases Middle Aged Morphology Neoplasm Grading Osteoblastoma Osteoblastoma - mortality Osteoblastoma - pathology Osteosarcoma Osteosarcoma - mortality Osteosarcoma - pathology prognosis Statistical analysis Surgery Tumors Young Adult |
| title | Osteoblastoma‐like osteosarcoma: high‐grade or low‐grade osteosarcoma? |
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