Comparative efficacy of ivermectin and Nigella sativa against helminths in Aseel chickens (Gallus gallus domesticus)
In this study, we evaluated the in vivo comparative efficacy of ivermectin and Nigella sativa extract against helminths in Aseel chickens, and the effects of helminths on blood parameters before and after treatment in Aseel chickens. Forty naturally infected adult Aseel chickens were randomly divide...
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| Veröffentlicht in: | Journal of helminthology 2019-09, Vol.93 (5), p.533-538 |
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| container_title | Journal of helminthology |
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| creator | Angel, C. Akhter, N. Arijo, A. Qureshi, T.A. Gandahi, J.A. Qazi, I.H. |
| description | In this study, we evaluated the in vivo comparative efficacy of ivermectin and Nigella sativa extract against helminths in Aseel chickens, and the effects of helminths on blood parameters before and after treatment in Aseel chickens. Forty naturally infected adult Aseel chickens were randomly divided into four groups (n = 10 each): group A (ivermectin at 300 μg/kg); group B (N. sativa extract at 200 mg/kg); group C (ivermectin at 300 μg/kg + N. sativa extract at 200 mg/kg); group D was kept as a positive control to monitor time-related changes. On day 28 post treatment, the mean percentages of faecal egg-count reduction (FECR %) in groups A, B and C were recorded as 93.58, 88.09 and 100.00%, respectively. Further data analysis showed significantly higher efficacy in group C (100 ± 0.00%) than in groups A and B (P < 0.001). Highly significant (P < 0.001) improvements in mean percentage values of packed cell volume (PCV %) were recorded in groups A and C on days 14 and 28 post treatment. Meanwhile, the improvements in mean values of haemoglobin (Hb) concentration in groups A, B and C were highly significant (P < 0.001) when compared to that of group D on day 28 post treatment. The synergistic combination of ivermectin and N. sativa extract possessed greater efficacy than either ivermectin or N. sativa extract used alone. Furthermore, both PCV % and Hb concentration values gradually increased in the treated groups compared to the control group, in which PCV % and Hb concentration gradually decreased throughout the trial. |
| doi_str_mv | 10.1017/S0022149X18000718 |
| format | Article |
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Forty naturally infected adult Aseel chickens were randomly divided into four groups (n = 10 each): group A (ivermectin at 300 μg/kg); group B (N. sativa extract at 200 mg/kg); group C (ivermectin at 300 μg/kg + N. sativa extract at 200 mg/kg); group D was kept as a positive control to monitor time-related changes. On day 28 post treatment, the mean percentages of faecal egg-count reduction (FECR %) in groups A, B and C were recorded as 93.58, 88.09 and 100.00%, respectively. Further data analysis showed significantly higher efficacy in group C (100 ± 0.00%) than in groups A and B (P < 0.001). Highly significant (P < 0.001) improvements in mean percentage values of packed cell volume (PCV %) were recorded in groups A and C on days 14 and 28 post treatment. Meanwhile, the improvements in mean values of haemoglobin (Hb) concentration in groups A, B and C were highly significant (P < 0.001) when compared to that of group D on day 28 post treatment. The synergistic combination of ivermectin and N. sativa extract possessed greater efficacy than either ivermectin or N. sativa extract used alone. Furthermore, both PCV % and Hb concentration values gradually increased in the treated groups compared to the control group, in which PCV % and Hb concentration gradually decreased throughout the trial.</description><identifier>ISSN: 0022-149X</identifier><identifier>EISSN: 1475-2697</identifier><identifier>DOI: 10.1017/S0022149X18000718</identifier><identifier>PMID: 30149818</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Animal sciences ; Bhutto, Benazir ; Birds ; Cell size ; Chickens ; Data analysis ; Effectiveness ; Farmers ; Hemoglobin ; Herbal medicine ; In vivo methods and tests ; Infections ; Ivermectin ; Nigella sativa ; Ova ; Parasites ; Poultry ; Research Paper ; Rural areas ; Seeds ; Studies ; Worms</subject><ispartof>Journal of helminthology, 2019-09, Vol.93 (5), p.533-538</ispartof><rights>Copyright © Cambridge University Press 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-4c3a74f5eea0488c67bbd5eb3bb0a6a6412a47c74d0930dadc5a1cf3885ab863</citedby><cites>FETCH-LOGICAL-c416t-4c3a74f5eea0488c67bbd5eb3bb0a6a6412a47c74d0930dadc5a1cf3885ab863</cites><orcidid>0000-0002-3052-0109</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022149X18000718/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30149818$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Angel, C.</creatorcontrib><creatorcontrib>Akhter, N.</creatorcontrib><creatorcontrib>Arijo, A.</creatorcontrib><creatorcontrib>Qureshi, T.A.</creatorcontrib><creatorcontrib>Gandahi, J.A.</creatorcontrib><creatorcontrib>Qazi, I.H.</creatorcontrib><title>Comparative efficacy of ivermectin and Nigella sativa against helminths in Aseel chickens (Gallus gallus domesticus)</title><title>Journal of helminthology</title><addtitle>J. Helminthol</addtitle><description>In this study, we evaluated the in vivo comparative efficacy of ivermectin and Nigella sativa extract against helminths in Aseel chickens, and the effects of helminths on blood parameters before and after treatment in Aseel chickens. Forty naturally infected adult Aseel chickens were randomly divided into four groups (n = 10 each): group A (ivermectin at 300 μg/kg); group B (N. sativa extract at 200 mg/kg); group C (ivermectin at 300 μg/kg + N. sativa extract at 200 mg/kg); group D was kept as a positive control to monitor time-related changes. On day 28 post treatment, the mean percentages of faecal egg-count reduction (FECR %) in groups A, B and C were recorded as 93.58, 88.09 and 100.00%, respectively. Further data analysis showed significantly higher efficacy in group C (100 ± 0.00%) than in groups A and B (P < 0.001). Highly significant (P < 0.001) improvements in mean percentage values of packed cell volume (PCV %) were recorded in groups A and C on days 14 and 28 post treatment. Meanwhile, the improvements in mean values of haemoglobin (Hb) concentration in groups A, B and C were highly significant (P < 0.001) when compared to that of group D on day 28 post treatment. The synergistic combination of ivermectin and N. sativa extract possessed greater efficacy than either ivermectin or N. sativa extract used alone. Furthermore, both PCV % and Hb concentration values gradually increased in the treated groups compared to the control group, in which PCV % and Hb concentration gradually decreased throughout the trial.</description><subject>Animal sciences</subject><subject>Bhutto, Benazir</subject><subject>Birds</subject><subject>Cell size</subject><subject>Chickens</subject><subject>Data analysis</subject><subject>Effectiveness</subject><subject>Farmers</subject><subject>Hemoglobin</subject><subject>Herbal medicine</subject><subject>In vivo methods and tests</subject><subject>Infections</subject><subject>Ivermectin</subject><subject>Nigella sativa</subject><subject>Ova</subject><subject>Parasites</subject><subject>Poultry</subject><subject>Research Paper</subject><subject>Rural areas</subject><subject>Seeds</subject><subject>Studies</subject><subject>Worms</subject><issn>0022-149X</issn><issn>1475-2697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kUtLxDAQx4Mouj4-gBcJeNFDNa822aMsvkD0oAdvZZpOd6N9rEkr-O1N2VVB8TQk85v_PP6EHHJ2xhnX54-MCcHV9JkbxpjmZoNMuNJpIrKp3iSTMZ2M-R2yG8JLZCQX6TbZkSz-Gm4mpJ91zRI89O4dKVaVs2A_aFfR-PYN2t61FNqS3rs51jXQMJJAYQ6uDT1dYN24tl8EGrmLgFhTu3D2FdtAT66hrodA56tQdg2G3tkhnO6TrQrqgAfruEeeri6fZjfJ3cP17eziLrGKZ32irAStqhQRmDLGZrooyhQLWRQMMsgUF6C01apkU8lKKG0K3FbSmBQKk8k9crKSXfrubYjN88YFO67RYjeEXLBpmkoj-Yge_0JfusG3cbhcCKG1iucaKb6irO9C8FjlS-8a8B85Z_noSP7HkVhztFYeigbL74ovCyIg16LQFN6Vc_zp_b_sJ4EKlso</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Angel, C.</creator><creator>Akhter, N.</creator><creator>Arijo, A.</creator><creator>Qureshi, T.A.</creator><creator>Gandahi, J.A.</creator><creator>Qazi, I.H.</creator><general>Cambridge University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7SN</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H95</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3052-0109</orcidid></search><sort><creationdate>201909</creationdate><title>Comparative efficacy of ivermectin and Nigella sativa against helminths in Aseel chickens (Gallus gallus domesticus)</title><author>Angel, C. ; 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Helminthol</addtitle><date>2019-09</date><risdate>2019</risdate><volume>93</volume><issue>5</issue><spage>533</spage><epage>538</epage><pages>533-538</pages><issn>0022-149X</issn><eissn>1475-2697</eissn><abstract>In this study, we evaluated the in vivo comparative efficacy of ivermectin and Nigella sativa extract against helminths in Aseel chickens, and the effects of helminths on blood parameters before and after treatment in Aseel chickens. Forty naturally infected adult Aseel chickens were randomly divided into four groups (n = 10 each): group A (ivermectin at 300 μg/kg); group B (N. sativa extract at 200 mg/kg); group C (ivermectin at 300 μg/kg + N. sativa extract at 200 mg/kg); group D was kept as a positive control to monitor time-related changes. On day 28 post treatment, the mean percentages of faecal egg-count reduction (FECR %) in groups A, B and C were recorded as 93.58, 88.09 and 100.00%, respectively. Further data analysis showed significantly higher efficacy in group C (100 ± 0.00%) than in groups A and B (P < 0.001). Highly significant (P < 0.001) improvements in mean percentage values of packed cell volume (PCV %) were recorded in groups A and C on days 14 and 28 post treatment. Meanwhile, the improvements in mean values of haemoglobin (Hb) concentration in groups A, B and C were highly significant (P < 0.001) when compared to that of group D on day 28 post treatment. The synergistic combination of ivermectin and N. sativa extract possessed greater efficacy than either ivermectin or N. sativa extract used alone. Furthermore, both PCV % and Hb concentration values gradually increased in the treated groups compared to the control group, in which PCV % and Hb concentration gradually decreased throughout the trial.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>30149818</pmid><doi>10.1017/S0022149X18000718</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3052-0109</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animal sciences Bhutto, Benazir Birds Cell size Chickens Data analysis Effectiveness Farmers Hemoglobin Herbal medicine In vivo methods and tests Infections Ivermectin Nigella sativa Ova Parasites Poultry Research Paper Rural areas Seeds Studies Worms |
| title | Comparative efficacy of ivermectin and Nigella sativa against helminths in Aseel chickens (Gallus gallus domesticus) |
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