Non-cardiac Chest Pain and Anxiety: A Possible Link to Vitamin D and Calcium
This study was performed to check the hypothesis that low serum vitamin D and reduced calcium intake may contribute to the comorbidity of psychological symptoms (anxiety and depression) and non-cardiac chest pain (NCCP). The design was a case–control study that involved 40 subjects with NCCP and 40...
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Veröffentlicht in: | Journal of clinical psychology in medical settings 2019-06, Vol.26 (2), p.194-199 |
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creator | Alkhatatbeh, Mohammad J. Abdul-Razzak, Khalid K. Amara, Noor A. Al-Jarrah, Mohamad |
description | This study was performed to check the hypothesis that low serum vitamin D and reduced calcium intake may contribute to the comorbidity of psychological symptoms (anxiety and depression) and non-cardiac chest pain (NCCP). The design was a case–control study that involved 40 subjects with NCCP and 40 age and gender-matched healthy controls. Serum vitamin D was assessed using electrochemiluminescence immunoassay; anxiety and depression symptoms were assessed using Hospital Anxiety and Depression Scale, and dietary calcium intake was assessed by self-reporting. Subjects with NCCP had higher anxiety and depression scores and lower vitamin D and dietary calcium intake compared to healthy controls (
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p
< .05). NCCP was associated with anxiety score (odds ratio = 1.40,
p
< .01). Prevalence of abnormal anxiety score was much higher in subjects with NCCP (47.5%) compared to healthy controls (7.5%). Anxiety score was inversely correlated with vitamin D level and dietary calcium intake (
p
< .01). Anxiety score was inversely associated with vitamin D level (
R
2
= .32,
p
< .05). In conclusion, development of NCCP can be predicted from increased anxiety score which in turn can be predicted from low vitamin D levels. This suggests physicians to consider anxiety and vitamin D deficiency as possible causes for NCCP.</description><identifier>ISSN: 1068-9583</identifier><identifier>EISSN: 1573-3572</identifier><identifier>DOI: 10.1007/s10880-018-9579-2</identifier><identifier>PMID: 30151664</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Age ; Angina pectoris ; Anxiety ; Anxiety Disorders - blood ; Anxiety Disorders - complications ; Anxiety Disorders - psychology ; Body mass index ; Calcium, Dietary - administration & dosage ; Calcium, Dietary - blood ; Cardiac catheterization ; Cardiovascular disease ; Case-Control Studies ; Chest Pain - blood ; Chest Pain - complications ; Chest Pain - psychology ; Chi-square test ; Chronic illnesses ; Dairy products ; Family Medicine ; Female ; Gender ; General Practice ; Health Psychology ; Hospitals ; Humans ; Intubation ; Male ; Medicine ; Medicine & Public Health ; Mental depression ; Milk ; Pain ; Regression analysis ; Self Report ; Variables ; Vitamin D ; Vitamin D - blood</subject><ispartof>Journal of clinical psychology in medical settings, 2019-06, Vol.26 (2), p.194-199</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-b8c47592eb736d362037c15d6e63fd7ee8a54f84242103032383a14470cd32843</citedby><cites>FETCH-LOGICAL-c372t-b8c47592eb736d362037c15d6e63fd7ee8a54f84242103032383a14470cd32843</cites><orcidid>0000-0002-9490-0979</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2804068477/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2804068477?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21387,21388,27923,27924,33529,33530,33743,33744,41487,42556,43658,43804,51318,64384,64386,64388,72340,73975,74173</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30151664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alkhatatbeh, Mohammad J.</creatorcontrib><creatorcontrib>Abdul-Razzak, Khalid K.</creatorcontrib><creatorcontrib>Amara, Noor A.</creatorcontrib><creatorcontrib>Al-Jarrah, Mohamad</creatorcontrib><title>Non-cardiac Chest Pain and Anxiety: A Possible Link to Vitamin D and Calcium</title><title>Journal of clinical psychology in medical settings</title><addtitle>J Clin Psychol Med Settings</addtitle><addtitle>J Clin Psychol Med Settings</addtitle><description>This study was performed to check the hypothesis that low serum vitamin D and reduced calcium intake may contribute to the comorbidity of psychological symptoms (anxiety and depression) and non-cardiac chest pain (NCCP). The design was a case–control study that involved 40 subjects with NCCP and 40 age and gender-matched healthy controls. Serum vitamin D was assessed using electrochemiluminescence immunoassay; anxiety and depression symptoms were assessed using Hospital Anxiety and Depression Scale, and dietary calcium intake was assessed by self-reporting. Subjects with NCCP had higher anxiety and depression scores and lower vitamin D and dietary calcium intake compared to healthy controls (
p
< .05). NCCP was associated with anxiety score (odds ratio = 1.40,
p
< .01). Prevalence of abnormal anxiety score was much higher in subjects with NCCP (47.5%) compared to healthy controls (7.5%). Anxiety score was inversely correlated with vitamin D level and dietary calcium intake (
p
< .01). Anxiety score was inversely associated with vitamin D level (
R
2
= .32,
p
< .05). In conclusion, development of NCCP can be predicted from increased anxiety score which in turn can be predicted from low vitamin D levels. This suggests physicians to consider anxiety and vitamin D deficiency as possible causes for NCCP.</description><subject>Adult</subject><subject>Age</subject><subject>Angina pectoris</subject><subject>Anxiety</subject><subject>Anxiety Disorders - blood</subject><subject>Anxiety Disorders - complications</subject><subject>Anxiety Disorders - psychology</subject><subject>Body mass index</subject><subject>Calcium, Dietary - administration & dosage</subject><subject>Calcium, Dietary - blood</subject><subject>Cardiac catheterization</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Chest Pain - blood</subject><subject>Chest Pain - complications</subject><subject>Chest Pain - psychology</subject><subject>Chi-square test</subject><subject>Chronic illnesses</subject><subject>Dairy products</subject><subject>Family Medicine</subject><subject>Female</subject><subject>Gender</subject><subject>General Practice</subject><subject>Health Psychology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Intubation</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Milk</subject><subject>Pain</subject><subject>Regression analysis</subject><subject>Self Report</subject><subject>Variables</subject><subject>Vitamin D</subject><subject>Vitamin D - blood</subject><issn>1068-9583</issn><issn>1573-3572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kEtLAzEQx4MotlY_gBcJePGyOnltst7K-oSiPajXkGZTTd1H3eyC_fam1gcIniYwv_nP5IfQIYFTAiDPAgGlIAGikkzILKFbaEiEZAkTkm7HN6TrjmIDtBfCAgAyxeguGjAggqQpH6LJXVMn1rSFNxbnLy50eGp8jU1d4HH97l23OsdjPG1C8LPS4YmvX3HX4CffmSpyF59kbkrr-2of7cxNGdzBVx2hx6vLh_wmmdxf3-bjSWKZpF0yU5ZLkVE3kywtWEqBSUtEkbqUzQvpnDKCzxWnnBJgwChTzBDOJdiCUcXZCJ1scpdt89bHm3Xlg3VlaWrX9EFTyISgWapERI__oIumb-t4naYKeBTEpYwU2VC2jR9t3VwvW1-ZdqUJ6LVqvVGto2q9Vq1pnDn6Su5nlSt-Jr7dRoBugBBb9bNrf1f_n_oBCVmE4Q</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Alkhatatbeh, Mohammad J.</creator><creator>Abdul-Razzak, Khalid K.</creator><creator>Amara, Noor A.</creator><creator>Al-Jarrah, Mohamad</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9490-0979</orcidid></search><sort><creationdate>20190601</creationdate><title>Non-cardiac Chest Pain and Anxiety: A Possible Link to Vitamin D and Calcium</title><author>Alkhatatbeh, Mohammad J. ; Abdul-Razzak, Khalid K. ; Amara, Noor A. ; Al-Jarrah, Mohamad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-b8c47592eb736d362037c15d6e63fd7ee8a54f84242103032383a14470cd32843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age</topic><topic>Angina pectoris</topic><topic>Anxiety</topic><topic>Anxiety Disorders - blood</topic><topic>Anxiety Disorders - complications</topic><topic>Anxiety Disorders - psychology</topic><topic>Body mass index</topic><topic>Calcium, Dietary - administration & dosage</topic><topic>Calcium, Dietary - blood</topic><topic>Cardiac catheterization</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Chest Pain - blood</topic><topic>Chest Pain - complications</topic><topic>Chest Pain - psychology</topic><topic>Chi-square test</topic><topic>Chronic illnesses</topic><topic>Dairy products</topic><topic>Family Medicine</topic><topic>Female</topic><topic>Gender</topic><topic>General Practice</topic><topic>Health Psychology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Intubation</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Milk</topic><topic>Pain</topic><topic>Regression analysis</topic><topic>Self Report</topic><topic>Variables</topic><topic>Vitamin D</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alkhatatbeh, Mohammad J.</creatorcontrib><creatorcontrib>Abdul-Razzak, Khalid K.</creatorcontrib><creatorcontrib>Amara, Noor A.</creatorcontrib><creatorcontrib>Al-Jarrah, Mohamad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical psychology in medical settings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alkhatatbeh, Mohammad J.</au><au>Abdul-Razzak, Khalid K.</au><au>Amara, Noor A.</au><au>Al-Jarrah, Mohamad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-cardiac Chest Pain and Anxiety: A Possible Link to Vitamin D and Calcium</atitle><jtitle>Journal of clinical psychology in medical settings</jtitle><stitle>J Clin Psychol Med Settings</stitle><addtitle>J Clin Psychol Med Settings</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>26</volume><issue>2</issue><spage>194</spage><epage>199</epage><pages>194-199</pages><issn>1068-9583</issn><eissn>1573-3572</eissn><abstract>This study was performed to check the hypothesis that low serum vitamin D and reduced calcium intake may contribute to the comorbidity of psychological symptoms (anxiety and depression) and non-cardiac chest pain (NCCP). The design was a case–control study that involved 40 subjects with NCCP and 40 age and gender-matched healthy controls. Serum vitamin D was assessed using electrochemiluminescence immunoassay; anxiety and depression symptoms were assessed using Hospital Anxiety and Depression Scale, and dietary calcium intake was assessed by self-reporting. Subjects with NCCP had higher anxiety and depression scores and lower vitamin D and dietary calcium intake compared to healthy controls (
p
< .05). NCCP was associated with anxiety score (odds ratio = 1.40,
p
< .01). Prevalence of abnormal anxiety score was much higher in subjects with NCCP (47.5%) compared to healthy controls (7.5%). Anxiety score was inversely correlated with vitamin D level and dietary calcium intake (
p
< .01). Anxiety score was inversely associated with vitamin D level (
R
2
= .32,
p
< .05). In conclusion, development of NCCP can be predicted from increased anxiety score which in turn can be predicted from low vitamin D levels. This suggests physicians to consider anxiety and vitamin D deficiency as possible causes for NCCP.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30151664</pmid><doi>10.1007/s10880-018-9579-2</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9490-0979</orcidid></addata></record> |
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source | MEDLINE; ProQuest Central (Alumni Edition); ProQuest Central UK/Ireland; SpringerLink Journals - AutoHoldings; ProQuest Central |
subjects | Adult Age Angina pectoris Anxiety Anxiety Disorders - blood Anxiety Disorders - complications Anxiety Disorders - psychology Body mass index Calcium, Dietary - administration & dosage Calcium, Dietary - blood Cardiac catheterization Cardiovascular disease Case-Control Studies Chest Pain - blood Chest Pain - complications Chest Pain - psychology Chi-square test Chronic illnesses Dairy products Family Medicine Female Gender General Practice Health Psychology Hospitals Humans Intubation Male Medicine Medicine & Public Health Mental depression Milk Pain Regression analysis Self Report Variables Vitamin D Vitamin D - blood |
title | Non-cardiac Chest Pain and Anxiety: A Possible Link to Vitamin D and Calcium |
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