Assessment of In Vitro Antioxidant activity of Some New Ferulic Acid Derivatives

The in vitro antioxidant potential of new thiazolidin-4-one derivatives of ferulic acid was evaluated according to the total antioxidant activity and ferric reducing power assays. The ferric reducing power assay was based on the reduction of ferricyanide to ferrocyanide, which form in the presence of ferric chloride a Perl Prussian blue color complex. The total antioxidant activity assay was assessed using phosphomolybdenum method. The results were expressed as effective concentration (EC50) values and ascorbic acid was used as positive control. All determinations were performed in triplicate. It was found that the activity of the tested compounds is influenced by the substituents on phenyl ring of the thiazolidine-4-one moiety. The most active compound was 1i, which contains 2,3-diOH as substituent on phenyl ring. A total of 10 new thiazolidin-4-one derivatives of ferulic acid were investigated for their in vitro antioxidant activity. The most active compound 1i (R=2,3-diOH) proved to be about 4 times more active than ferulic acid and comparable to ascorbic acid in both antioxidant assays.