Crystal Structure of a Prolactin Receptor Antagonist Bound to the Extracellular Domain of the Prolactin Receptor

The crystal structure of the complex between an N-terminally truncated G129R human prolactin (PRL) variant and the extracellular domain of the human prolactin receptor (PRLR) was determined at 2.5Å resolution by x-ray crystallography. This structure represents the first experimental structure report...

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Veröffentlicht in:	The Journal of biological chemistry 2008-07, Vol.283 (27), p.19085-19094
Hauptverfasser:	Svensson, L. Anders, Bondensgaard, Kent, Nørskov-Lauritsen, Leif, Christensen, Leif, Becker, Peter, Andersen, Mette D., Maltesen, Morten J., Rand, Kasper D., Breinholt, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Binding Sites - genetics Crystallography, X-Ray Humans Mutagenesis Nuclear Magnetic Resonance, Biomolecular Peptides - chemistry Peptides - genetics Peptides - metabolism Prolactin - chemistry Prolactin - genetics Prolactin - metabolism Protein Structure, Quaternary Protein Structure, Secondary Protein Structure, Tertiary - genetics Receptors, Prolactin - antagonists & inhibitors Receptors, Prolactin - chemistry Receptors, Prolactin - genetics Receptors, Prolactin - metabolism
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