Ketamine blocks enhancement of spinal long-term potentiation in chronic opioid treated rats

Background: Long‐term opioid treatment is associated with the development of hyperalgesia. In a rat model we wanted to study if chronic opioid treatment changed the induction and maintenance of spinal long‐term potentiation (LTP), a form of hyperexcitability in the spinal cord. We also wanted to inv...

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Veröffentlicht in:	Acta anaesthesiologica Scandinavica 2008-05, Vol.52 (5), p.681-687
Hauptverfasser:	HAUGAN, F., RYGH, L. J., TJØLSEN, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - adverse effects Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Dissociative - pharmacology Animals Biological and medical sciences central sensitization Chronic Disease chronic opioid treatment Drug Synergism Electric Stimulation - methods Female Hyperalgesia - chemically induced Hyperalgesia - prevention & control Ketamine - pharmacology long-term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Medical sciences Morphine - adverse effects Nerve Fibers, Unmyelinated - drug effects NMDA-R antagonists Nociception opioid tolerance Random Allocation Rats Rats, Sprague-Dawley spinal cord Spinal Cord - drug effects Time Factors
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