Polymorphisms in the aurora-A gene is not associated with lung cancer in the Turkish population
Lung cancer, a complex neoplasm of lung tissue, is influenced by several environmental and genetic factors which could be changed in each individual. Aurora-A gene is related to mitotic events such as: chromosome instability, cell cycle regulation, spindle formation, and kinetechore-microtubule conn...
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| Veröffentlicht in: | DNA and cell biology 2008-08, Vol.27 (8), p.443-448 |
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| container_title | DNA and cell biology |
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| creator | Dogan, Irem Ekmekci, Abdullah Yurdakul, Ahmet Selim Onen, Ilke Hacer Ozturk, Can Cirak, Meltem Yalinay Acar, Aysegul Konac, Ece |
| description | Lung cancer, a complex neoplasm of lung tissue, is influenced by several environmental and genetic factors which could be changed in each individual. Aurora-A gene is related to mitotic events such as: chromosome instability, cell cycle regulation, spindle formation, and kinetechore-microtubule connections. This centrosomic serine/threonine kinase provides a strong connection between mitotic errors and carcinogenesis. The genomic alterations such as single nucleotide polymorphisms (SNPs) can exist in molecular pathways of lung cancer. Therefore, we evaluated the role of genetic polymorphisms of Aurora-A gene in the lung cancer in the Turkish population. Genotypes of five Aurora-A polymorphisms (F31I, V57I, 6328G/A, P50L, and S104L) were determined in 102 healty controls and 102 new diagnosed lung cancer cases. All samples were genotyped with DNA sequence technique. There were not any genotype variations in P50L, S104L, and 6328G/A polymorphisms. The frequencies of both genotypes F31I and V57I in lung cancer patients were not significantly different from those in controls (p > 0.05). A multivariable logistic regression analysis including patient characteristics, such as age and gender, did not change the results. |
| doi_str_mv | 10.1089/dna.2007.0719 |
| format | Article |
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A multivariable logistic regression analysis including patient characteristics, such as age and gender, did not change the results.</description><subject>Aurora Kinases</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Reference Standards</subject><subject>Turkey - epidemiology</subject><issn>1044-5498</issn><issn>1557-7430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0D1PwzAQgGELgWgpjKzIE1vK2bFje6wqvqRKMJTZchOnNSR2sBOh_ntStYjpbnjuhhehWwJzAlI9VN7MKYCYgyDqDE0J5yITLIfzcQfGMs6UnKCrlD4BgFMCl2hCJCsKkGKK9Hto9m2I3c6lNmHncb-z2AwxRJMt8NZ6i13CPvTYpBRKZ3pb4R_X73Az-C0ujS9t_LtbD_HLpR3uQjc0pnfBX6OL2jTJ3pzmDH08Pa6XL9nq7fl1uVhlZU5pn4mKyZrnQPINWJJTzkvFmKK2FrWi9UYKoHaUzNra1EVeyIJVihWMF8RUqshn6P74t4vhe7Cp161LpW0a420YkqYwaqn4CLMjLGNIKdpad9G1Ju41AX0oqsei-lBUH4qO_u70eNi0tvrXp4T5LywrcXo</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Dogan, Irem</creator><creator>Ekmekci, Abdullah</creator><creator>Yurdakul, Ahmet Selim</creator><creator>Onen, Ilke Hacer</creator><creator>Ozturk, Can</creator><creator>Cirak, Meltem Yalinay</creator><creator>Acar, Aysegul</creator><creator>Konac, Ece</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>200808</creationdate><title>Polymorphisms in the aurora-A gene is not associated with lung cancer in the Turkish population</title><author>Dogan, Irem ; Ekmekci, Abdullah ; Yurdakul, Ahmet Selim ; Onen, Ilke Hacer ; Ozturk, Can ; Cirak, Meltem Yalinay ; Acar, Aysegul ; Konac, Ece</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-7d48f53013b0e13255c94492ef7f92fb8702e3224eefaf636864d9464561ad963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aurora Kinases</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Reference Standards</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dogan, Irem</creatorcontrib><creatorcontrib>Ekmekci, Abdullah</creatorcontrib><creatorcontrib>Yurdakul, Ahmet Selim</creatorcontrib><creatorcontrib>Onen, Ilke Hacer</creatorcontrib><creatorcontrib>Ozturk, Can</creatorcontrib><creatorcontrib>Cirak, Meltem Yalinay</creatorcontrib><creatorcontrib>Acar, Aysegul</creatorcontrib><creatorcontrib>Konac, Ece</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>DNA and cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dogan, Irem</au><au>Ekmekci, Abdullah</au><au>Yurdakul, Ahmet Selim</au><au>Onen, Ilke Hacer</au><au>Ozturk, Can</au><au>Cirak, Meltem Yalinay</au><au>Acar, Aysegul</au><au>Konac, Ece</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in the aurora-A gene is not associated with lung cancer in the Turkish population</atitle><jtitle>DNA and cell biology</jtitle><addtitle>DNA Cell Biol</addtitle><date>2008-08</date><risdate>2008</risdate><volume>27</volume><issue>8</issue><spage>443</spage><epage>448</epage><pages>443-448</pages><issn>1044-5498</issn><eissn>1557-7430</eissn><abstract>Lung cancer, a complex neoplasm of lung tissue, is influenced by several environmental and genetic factors which could be changed in each individual. Aurora-A gene is related to mitotic events such as: chromosome instability, cell cycle regulation, spindle formation, and kinetechore-microtubule connections. This centrosomic serine/threonine kinase provides a strong connection between mitotic errors and carcinogenesis. The genomic alterations such as single nucleotide polymorphisms (SNPs) can exist in molecular pathways of lung cancer. Therefore, we evaluated the role of genetic polymorphisms of Aurora-A gene in the lung cancer in the Turkish population. Genotypes of five Aurora-A polymorphisms (F31I, V57I, 6328G/A, P50L, and S104L) were determined in 102 healty controls and 102 new diagnosed lung cancer cases. All samples were genotyped with DNA sequence technique. There were not any genotype variations in P50L, S104L, and 6328G/A polymorphisms. The frequencies of both genotypes F31I and V57I in lung cancer patients were not significantly different from those in controls (p > 0.05). 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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aurora Kinases Female Humans Lung Neoplasms - epidemiology Lung Neoplasms - genetics Male Middle Aged Polymorphism, Genetic Protein-Serine-Threonine Kinases - genetics Reference Standards Turkey - epidemiology |
| title | Polymorphisms in the aurora-A gene is not associated with lung cancer in the Turkish population |
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