Substrate-targeting big gamma-secretase modulators

Selective lowering of Abeta42 levels (the 42-residue isoform of the amyloid-beta peptide) with small-molecule gamma-secretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therapeutic approach for Alzheimer's disease. To identify the target of these agent...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nature 2008-06, Vol.453 (7197), p.925-929
Hauptverfasser:	Kukar, Thomas L, Ladd, Thomas B, Bann, Maralyssa A, Fraering, Patrick C, Narlawar, Rajeshwar, Maharvi, Ghulam M, Healy, Brent, Chapman, Robert, Welzel, Alfred T, Price, Robert W, Moore, Brenda, Rangachari, Vijayaraghavan, Cusack, Bernadette, Eriksen, Jason, Jansen-West, Karen, Verbeeck, Christophe, Yager, Debra, Eckman, Christopher, Ye, Wenjuan, Sagi, Sarah, Cottrell, Barbara A, Torpey, Justin, Rosenberry, Terrone L, Fauq, Abdul, Wolfe, Michael S, Schmidt, Boris, Walsh, Dominic M, Koo, Edward H, Golde, Todd E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!