Targeted capture sequencing identifies novel genetic variations in Chinese patients with idiopathic inflammatory myopathies

Objectives Previous association studies have identified genetic variants in the human leukocyte antigen (HLA) complex as substantial risk factors for idiopathic inflammatory myopathies (IIMs). However, a great number of genes are located in the HLA region, and thus fine mapping is quite necessary. M...

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Veröffentlicht in:	International journal of rheumatic diseases 2018-08, Vol.21 (8), p.1619-1626
Hauptverfasser:	Peng, Qing‐Lin, Lin, Jin‐Ming, Zhang, Yong‐Biao, Zhang, Xue‐Zhi, Wang, Pan‐Pan, Wu, Ting‐Ting, Yu, Jun, Dong, Xiao‐Qun, Gu, Ming‐Liang, Wang, Guo‐Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens Asian Continental Ancestry Group - genetics Case-Control Studies China - epidemiology dermatomyositis DNA microarrays DQA1 protein Drb1 protein Female Gene expression Gene Expression Profiling - methods Gene mapping gene polymorphism Genetic Association Studies Genetic diversity Genetic Predisposition to Disease Genetic Variation High-Throughput Nucleotide Sequencing Histocompatibility antigen HLA HLA Antigens - genetics HLA Antigens - immunology human leukocyte antigen polymyositis Humans Inflammation Male Middle Aged Myositis - diagnosis Myositis - ethnology Myositis - genetics Myositis - immunology Oligonucleotide Array Sequence Analysis Phenotype Predictive Value of Tests Risk Factors Transcriptome
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