The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain

Gene regulation requires selective targeting of DNA regulatory enhancers over megabase distances. Here we show that Evf2, a cloud-forming Dlx5/6 ultraconserved enhancer (UCE) lncRNA, simultaneously localizes to activated (Umad1, 1.6 Mb distant) and repressed (Akr1b8, 27 Mb distant) chr6 target genes...

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Veröffentlicht in:	Molecular cell 2018-09, Vol.71 (6), p.956-972.e9
Hauptverfasser:	Cajigas, Ivelisse, Chakraborty, Abhijit, Swyter, Kelsey R., Luo, Hao, Bastidas, Monique, Nigro, Maximilliano, Morris, Elizabeth R., Chen, Sean, VanGompel, Michael J.W., Leib, David, Kohtz, Sara J., Martina, Marco, Koh, Sooky, Ay, Ferhat, Kohtz, Jhumku D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - genetics aldo-ketoreductase 1b8/1b10 Animals brain Cell Cycle Proteins - genetics Chromosomal Proteins, Non-Histone - genetics chromosome 3D structure chromosomes Cohesins Conserved Sequence DNA enhancer Enhancer Elements, Genetic - genetics gene expression Gene Expression Regulation, Developmental - genetics genes Homeodomain Proteins - genetics Homeodomain Proteins - physiology interneuron diversity interneurons Interneurons - physiology long non-coding RNA mevalonate pathway Mice Neurogenesis - genetics Neurogenesis - physiology Prosencephalon - embryology RNA RNA, Long Noncoding - genetics seizure susceptibility serotonin receptor Htr3a topology transcription transcription (genetics) Transcription Factors ultraconserved
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