Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway
Background Nuciferine, a major bioactive component from the lotus leaf , has been reported to have notable anti-inflammatory activities such as renal inflammation and acute lung injury in previous studies. Mastitis is one of the most prevalent diseases in the dairy cattle, which causes large economi...
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| Veröffentlicht in: | Inflammation research 2018-12, Vol.67 (11-12), p.903-911 |
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| creator | Chen, Xingxing Zheng, Xintian Zhang, Min Yin, Huifang Jiang, Kangfeng Wu, Haichong Dai, Ailing Yang, Shoushen |
| description | Background
Nuciferine, a major bioactive component from the
lotus leaf
, has been reported to have notable anti-inflammatory activities such as renal inflammation and acute lung injury in previous studies. Mastitis is one of the most prevalent diseases in the dairy cattle, which causes large economic losses for the dairy industry. However, the effects of nuciferine on lipopolysaccharide (LPS)-induced mastitis have not been reported.
Methods and results
Here, we investigated the anti-inflammatory effects of nuciferine on LPS-induced mastitis in mice and illuminated its potential mechanism on the TLR4-mediated signaling pathway in mouse mammary epithelial cells (mMECs). Histopathological changes and myeloperoxidase (MPO) activity assay showed that nuciferine treatment significantly alleviated the LPS-induced injury of mammary gland flocculus, inflammatory cells infiltration. qPCR and ELISA assays indicated that nuciferine dose-dependently reduced the levels of TNF-α and IL-1β, which indicated that nuciferine might have therapeutic effects on mastitis. Furthermore, nuciferine treatment significantly decreased the expression of TLR4 in a dose-dependent manner. Besides, nuciferine was also found to suppress LPS-induced NF-κB activation.
Conclusion
These findings indicate that nuciferine potently ameliorates LPS-induced mastitis by inhibition of the TLR4-NF-κB signaling pathway. |
| doi_str_mv | 10.1007/s00011-018-1183-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2094418769</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2094418769</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2872-4277e0bc82eab726db6bd926314a6c9ae555dd80859f4beae2fc9889364bca583</originalsourceid><addsrcrecordid>eNp1kd9q1UAQxpeitLX6AL0pC970ZnX2T5LNpZZWhUOVtoJ3y2YzOd2S5MSdpNJX8yF8Jvd4qoLg1QzMb74Zvo-xYwmvJED1mgBASgHSCimtFmqPHUqjQNRgvzzJPSgttNVwwJ4R3WXaKqv22YEGaYqy0IesvVxC7DDFEbnve7yPfkbiq0_XIo7tErDlg6c5zpF4HPkQA_LMcFqmKSFRHNd8vkV-s7oy4vJC_Pj-llNcj77fTiY_337zD8_Z0873hC8e6xH7fHF-c_ZerD6--3D2ZiWCspUSRlUVQhOsQt9UqmybsmlrVWppfBlqj0VRtK0FW9SdadCj6kJtba1L0wRfWH3ETne6U9p8XZBmN0QK2Pd-xM1CTkFtjLRVWWf05T_o3WZJ-e1fVPZHgZaZkjsqpA1Rws5NKQ4-PTgJbhuB20XgcgRuG4FTeefkUXlpBmz_bPz2PANqB1AejWtMf0__X_UntmuQ9Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2093012031</pqid></control><display><type>article</type><title>Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Chen, Xingxing ; Zheng, Xintian ; Zhang, Min ; Yin, Huifang ; Jiang, Kangfeng ; Wu, Haichong ; Dai, Ailing ; Yang, Shoushen</creator><creatorcontrib>Chen, Xingxing ; Zheng, Xintian ; Zhang, Min ; Yin, Huifang ; Jiang, Kangfeng ; Wu, Haichong ; Dai, Ailing ; Yang, Shoushen</creatorcontrib><description>Background
Nuciferine, a major bioactive component from the
lotus leaf
, has been reported to have notable anti-inflammatory activities such as renal inflammation and acute lung injury in previous studies. Mastitis is one of the most prevalent diseases in the dairy cattle, which causes large economic losses for the dairy industry. However, the effects of nuciferine on lipopolysaccharide (LPS)-induced mastitis have not been reported.
Methods and results
Here, we investigated the anti-inflammatory effects of nuciferine on LPS-induced mastitis in mice and illuminated its potential mechanism on the TLR4-mediated signaling pathway in mouse mammary epithelial cells (mMECs). Histopathological changes and myeloperoxidase (MPO) activity assay showed that nuciferine treatment significantly alleviated the LPS-induced injury of mammary gland flocculus, inflammatory cells infiltration. qPCR and ELISA assays indicated that nuciferine dose-dependently reduced the levels of TNF-α and IL-1β, which indicated that nuciferine might have therapeutic effects on mastitis. Furthermore, nuciferine treatment significantly decreased the expression of TLR4 in a dose-dependent manner. Besides, nuciferine was also found to suppress LPS-induced NF-κB activation.
Conclusion
These findings indicate that nuciferine potently ameliorates LPS-induced mastitis by inhibition of the TLR4-NF-κB signaling pathway.</description><identifier>ISSN: 1023-3830</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s00011-018-1183-2</identifier><identifier>PMID: 30145653</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Allergology ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Aporphines - pharmacology ; Aporphines - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Cattle ; Cells, Cultured ; Dairy industry ; Dermatology ; Economic impact ; Enzyme-linked immunosorbent assay ; Epithelial cells ; Epithelial Cells - drug effects ; Epithelial Cells - metabolism ; Female ; IL-1β ; Immunology ; Infiltration ; Inflammation ; Interleukin-1beta - genetics ; Interleukin-1beta - metabolism ; Lipopolysaccharides ; Lungs ; Mammary gland ; Mammary glands ; Mammary Glands, Animal - cytology ; Mammary Glands, Animal - drug effects ; Mammary Glands, Animal - metabolism ; Mammary Glands, Animal - pathology ; Mastitis ; Mastitis - chemically induced ; Mastitis - drug therapy ; Mastitis - metabolism ; Mastitis - pathology ; Mice ; Mice, Inbred BALB C ; Neurology ; NF-kappa B - metabolism ; NF-κB protein ; Original Research Paper ; Peroxidase ; Pharmacology/Toxicology ; Rheumatology ; Rodents ; Signal transduction ; Signal Transduction - drug effects ; Signaling ; TLR4 protein ; Toll-Like Receptor 4 - metabolism ; Toll-like receptors ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factor-α</subject><ispartof>Inflammation research, 2018-12, Vol.67 (11-12), p.903-911</ispartof><rights>Springer Nature Switzerland AG 2018</rights><rights>Inflammation Research is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2872-4277e0bc82eab726db6bd926314a6c9ae555dd80859f4beae2fc9889364bca583</citedby><cites>FETCH-LOGICAL-c2872-4277e0bc82eab726db6bd926314a6c9ae555dd80859f4beae2fc9889364bca583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00011-018-1183-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00011-018-1183-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30145653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Xingxing</creatorcontrib><creatorcontrib>Zheng, Xintian</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><creatorcontrib>Yin, Huifang</creatorcontrib><creatorcontrib>Jiang, Kangfeng</creatorcontrib><creatorcontrib>Wu, Haichong</creatorcontrib><creatorcontrib>Dai, Ailing</creatorcontrib><creatorcontrib>Yang, Shoushen</creatorcontrib><title>Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway</title><title>Inflammation research</title><addtitle>Inflamm. Res</addtitle><addtitle>Inflamm Res</addtitle><description>Background
Nuciferine, a major bioactive component from the
lotus leaf
, has been reported to have notable anti-inflammatory activities such as renal inflammation and acute lung injury in previous studies. Mastitis is one of the most prevalent diseases in the dairy cattle, which causes large economic losses for the dairy industry. However, the effects of nuciferine on lipopolysaccharide (LPS)-induced mastitis have not been reported.
Methods and results
Here, we investigated the anti-inflammatory effects of nuciferine on LPS-induced mastitis in mice and illuminated its potential mechanism on the TLR4-mediated signaling pathway in mouse mammary epithelial cells (mMECs). Histopathological changes and myeloperoxidase (MPO) activity assay showed that nuciferine treatment significantly alleviated the LPS-induced injury of mammary gland flocculus, inflammatory cells infiltration. qPCR and ELISA assays indicated that nuciferine dose-dependently reduced the levels of TNF-α and IL-1β, which indicated that nuciferine might have therapeutic effects on mastitis. Furthermore, nuciferine treatment significantly decreased the expression of TLR4 in a dose-dependent manner. Besides, nuciferine was also found to suppress LPS-induced NF-κB activation.
Conclusion
These findings indicate that nuciferine potently ameliorates LPS-induced mastitis by inhibition of the TLR4-NF-κB signaling pathway.</description><subject>Allergology</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Aporphines - pharmacology</subject><subject>Aporphines - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cattle</subject><subject>Cells, Cultured</subject><subject>Dairy industry</subject><subject>Dermatology</subject><subject>Economic impact</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epithelial cells</subject><subject>Epithelial Cells - drug effects</subject><subject>Epithelial Cells - metabolism</subject><subject>Female</subject><subject>IL-1β</subject><subject>Immunology</subject><subject>Infiltration</subject><subject>Inflammation</subject><subject>Interleukin-1beta - genetics</subject><subject>Interleukin-1beta - metabolism</subject><subject>Lipopolysaccharides</subject><subject>Lungs</subject><subject>Mammary gland</subject><subject>Mammary glands</subject><subject>Mammary Glands, Animal - cytology</subject><subject>Mammary Glands, Animal - drug effects</subject><subject>Mammary Glands, Animal - metabolism</subject><subject>Mammary Glands, Animal - pathology</subject><subject>Mastitis</subject><subject>Mastitis - chemically induced</subject><subject>Mastitis - drug therapy</subject><subject>Mastitis - metabolism</subject><subject>Mastitis - pathology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Neurology</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Original Research Paper</subject><subject>Peroxidase</subject><subject>Pharmacology/Toxicology</subject><subject>Rheumatology</subject><subject>Rodents</subject><subject>Signal transduction</subject><subject>Signal Transduction - drug effects</subject><subject>Signaling</subject><subject>TLR4 protein</subject><subject>Toll-Like Receptor 4 - metabolism</subject><subject>Toll-like receptors</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor necrosis factor-α</subject><issn>1023-3830</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kd9q1UAQxpeitLX6AL0pC970ZnX2T5LNpZZWhUOVtoJ3y2YzOd2S5MSdpNJX8yF8Jvd4qoLg1QzMb74Zvo-xYwmvJED1mgBASgHSCimtFmqPHUqjQNRgvzzJPSgttNVwwJ4R3WXaKqv22YEGaYqy0IesvVxC7DDFEbnve7yPfkbiq0_XIo7tErDlg6c5zpF4HPkQA_LMcFqmKSFRHNd8vkV-s7oy4vJC_Pj-llNcj77fTiY_337zD8_Z0873hC8e6xH7fHF-c_ZerD6--3D2ZiWCspUSRlUVQhOsQt9UqmybsmlrVWppfBlqj0VRtK0FW9SdadCj6kJtba1L0wRfWH3ETne6U9p8XZBmN0QK2Pd-xM1CTkFtjLRVWWf05T_o3WZJ-e1fVPZHgZaZkjsqpA1Rws5NKQ4-PTgJbhuB20XgcgRuG4FTeefkUXlpBmz_bPz2PANqB1AejWtMf0__X_UntmuQ9Q</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Chen, Xingxing</creator><creator>Zheng, Xintian</creator><creator>Zhang, Min</creator><creator>Yin, Huifang</creator><creator>Jiang, Kangfeng</creator><creator>Wu, Haichong</creator><creator>Dai, Ailing</creator><creator>Yang, Shoushen</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20181201</creationdate><title>Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway</title><author>Chen, Xingxing ; Zheng, Xintian ; Zhang, Min ; Yin, Huifang ; Jiang, Kangfeng ; Wu, Haichong ; Dai, Ailing ; Yang, Shoushen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2872-4277e0bc82eab726db6bd926314a6c9ae555dd80859f4beae2fc9889364bca583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Allergology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Aporphines - pharmacology</topic><topic>Aporphines - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cattle</topic><topic>Cells, Cultured</topic><topic>Dairy industry</topic><topic>Dermatology</topic><topic>Economic impact</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Epithelial cells</topic><topic>Epithelial Cells - drug effects</topic><topic>Epithelial Cells - metabolism</topic><topic>Female</topic><topic>IL-1β</topic><topic>Immunology</topic><topic>Infiltration</topic><topic>Inflammation</topic><topic>Interleukin-1beta - genetics</topic><topic>Interleukin-1beta - metabolism</topic><topic>Lipopolysaccharides</topic><topic>Lungs</topic><topic>Mammary gland</topic><topic>Mammary glands</topic><topic>Mammary Glands, Animal - cytology</topic><topic>Mammary Glands, Animal - drug effects</topic><topic>Mammary Glands, Animal - metabolism</topic><topic>Mammary Glands, Animal - pathology</topic><topic>Mastitis</topic><topic>Mastitis - chemically induced</topic><topic>Mastitis - drug therapy</topic><topic>Mastitis - metabolism</topic><topic>Mastitis - pathology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Neurology</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Original Research Paper</topic><topic>Peroxidase</topic><topic>Pharmacology/Toxicology</topic><topic>Rheumatology</topic><topic>Rodents</topic><topic>Signal transduction</topic><topic>Signal Transduction - drug effects</topic><topic>Signaling</topic><topic>TLR4 protein</topic><topic>Toll-Like Receptor 4 - metabolism</topic><topic>Toll-like receptors</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xingxing</creatorcontrib><creatorcontrib>Zheng, Xintian</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><creatorcontrib>Yin, Huifang</creatorcontrib><creatorcontrib>Jiang, Kangfeng</creatorcontrib><creatorcontrib>Wu, Haichong</creatorcontrib><creatorcontrib>Dai, Ailing</creatorcontrib><creatorcontrib>Yang, Shoushen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xingxing</au><au>Zheng, Xintian</au><au>Zhang, Min</au><au>Yin, Huifang</au><au>Jiang, Kangfeng</au><au>Wu, Haichong</au><au>Dai, Ailing</au><au>Yang, Shoushen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway</atitle><jtitle>Inflammation research</jtitle><stitle>Inflamm. Res</stitle><addtitle>Inflamm Res</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>67</volume><issue>11-12</issue><spage>903</spage><epage>911</epage><pages>903-911</pages><issn>1023-3830</issn><eissn>1420-908X</eissn><abstract>Background
Nuciferine, a major bioactive component from the
lotus leaf
, has been reported to have notable anti-inflammatory activities such as renal inflammation and acute lung injury in previous studies. Mastitis is one of the most prevalent diseases in the dairy cattle, which causes large economic losses for the dairy industry. However, the effects of nuciferine on lipopolysaccharide (LPS)-induced mastitis have not been reported.
Methods and results
Here, we investigated the anti-inflammatory effects of nuciferine on LPS-induced mastitis in mice and illuminated its potential mechanism on the TLR4-mediated signaling pathway in mouse mammary epithelial cells (mMECs). Histopathological changes and myeloperoxidase (MPO) activity assay showed that nuciferine treatment significantly alleviated the LPS-induced injury of mammary gland flocculus, inflammatory cells infiltration. qPCR and ELISA assays indicated that nuciferine dose-dependently reduced the levels of TNF-α and IL-1β, which indicated that nuciferine might have therapeutic effects on mastitis. Furthermore, nuciferine treatment significantly decreased the expression of TLR4 in a dose-dependent manner. Besides, nuciferine was also found to suppress LPS-induced NF-κB activation.
Conclusion
These findings indicate that nuciferine potently ameliorates LPS-induced mastitis by inhibition of the TLR4-NF-κB signaling pathway.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30145653</pmid><doi>10.1007/s00011-018-1183-2</doi><tpages>9</tpages></addata></record> |
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| subjects | Allergology Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Aporphines - pharmacology Aporphines - therapeutic use Biomedical and Life Sciences Biomedicine Cattle Cells, Cultured Dairy industry Dermatology Economic impact Enzyme-linked immunosorbent assay Epithelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Female IL-1β Immunology Infiltration Inflammation Interleukin-1beta - genetics Interleukin-1beta - metabolism Lipopolysaccharides Lungs Mammary gland Mammary glands Mammary Glands, Animal - cytology Mammary Glands, Animal - drug effects Mammary Glands, Animal - metabolism Mammary Glands, Animal - pathology Mastitis Mastitis - chemically induced Mastitis - drug therapy Mastitis - metabolism Mastitis - pathology Mice Mice, Inbred BALB C Neurology NF-kappa B - metabolism NF-κB protein Original Research Paper Peroxidase Pharmacology/Toxicology Rheumatology Rodents Signal transduction Signal Transduction - drug effects Signaling TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α |
| title | Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway |
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