Acute Toxicity Study of a Simian Immunodeficiency Virus-Based Lentiviral Vector for Retinal Gene Transfer in Nonhuman Primates

A phase 1 clinical trial evaluating the safety of gene therapy for patients with wet age-related macular degeneration (AMD) or retinoblastoma has been completed without problems. The efficacy of gene therapy for Leber's congenital amaurosis (LCA) was reported by three groups. Gene therapy may t...

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Veröffentlicht in:	Human gene therapy 2009-09, Vol.20 (9), p.943-954
Hauptverfasser:	IKEDA, Yasuhiro, YONEMITSU, Yoshikazu, SUZUKI, Toshimichi, AGEYAMA, Naohide, TERAO, Keiji, HASEGAWA, Mamoru, SUEISHI, Katsuo, ISHIBASHI, Tatsuro, MIYAZAKI, Masanori, KOHNO, Ri-Ichiro, MURAKAMI, Yusuke, MURATA, Toshinori, GOTO, Yoshinobu, TABATA, Toshiaki, UEDA, Yasuji, ONO, Fumiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Cell Line Drug Evaluation, Preclinical Electroretinography Eye Proteins - genetics Fundamental and applied biological sciences. Psychology Gene therapy Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - adverse effects Green Fluorescent Proteins Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Macaca fascicularis Medical sciences Models, Animal Nerve Growth Factors - genetics Primates Retina - pathology Retina - virology Serpins - genetics Simian immunodeficiency virus Simian Immunodeficiency Virus - genetics Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenes Treatment Outcome
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